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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 759 - 763 (5page)
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For improved intracellular uptake of CpG ODN into macrophages, we developed CpG ODN and mannose conjugate (CpG-Man conjugate) via simple conjugation of ${\alpha}$-${\small{D}}$-mannose to CpG ODN. CpG-Man conjugate showed greatly enhanced intracellular uptake by 2.1-fold into macrophages, compared to CpG ODN in a TLR-9 receptor-specific manner. In addition, internalized CpG-Man conjugate successfully triggered TNF-${\alpha}$ release in macrophages. Taken together, the CpG-Man conjugate can serve as the promising delivery systems of CpG ODN into immune cells as a candidate adjuvant.
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