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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 301 - 312 (12page)
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Metastasis is one of hallmarks of cancer and a major cause of cancer death. Combatting metastasis is highly challenging. To overcome these difficulties, researchers have focused on physical properties of metastatic cancer cells. Metastatic cancer cells from patients are softer than benign cancer or normal cells. Changes of viscoelasticity of cancer cells are related to the keratin network. Unexpectedly, keratin network is dynamic and regulation of keratin network is important to the metastasis of cancer. Keratin is composed of heteropolymer of type I and II. Keratin connects from the plasma membrane to nucleus. Several proteins including kinases, and protein phosphatases bind to keratin intermediate filaments. Several endogenous compounds or toxic compounds induce phosphorylation and reorganization of keratin network in cancer cells, leading to increased migration. Continuous phosphorylation of keratin results in loss of keratin, which is one of the features of epithelial mesenchymal transition (EMT). Therefore, several proteins involved in phosphorylation and reorganization of keratin also have a role in EMT. It is likely that compounds controlling phosphorylation and reorganization of keratin are potential candidates for combating EMT and metastasis.
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참고문헌 (122)
참고문헌 신청
Akita, Y. / 2007 / Protein kinase C epsilon phosphorylates keratin 8 at Ser8 and Ser23 in GH4C1 cells stimulated by thyrotropin-releasing hormone / FEBS J 274:3270~3285
Alam, H. / 2011 / Loss of keratin 8 phosphorylation leads to increased tumor progression and correlates with clinico-pathological parameters of OSCC patients / PLoS One :e27767
Ando, S. / 1996 / Keratin 8 phosphorylation in vitro by cAMP-dependent protein kinase occurs within the amino- and carboxyl-terminal end domains / Biochem. Biophys. Res. Commun 221:67~71
Baribault, H. / 1989 / Epidermal growth factor-induced selective phosphorylation of cultured rat hepatocyte 55-kD cytokeratin before fi lament reorganization and DNA synthesis / J. Cell Biol 109:1665~1676
Beil, M. / 2003 / Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells / Nat. Cell Biol 5:803~811
Alam, H. / 2011 / Loss of keratin 8 phosphorylation leads to increased tumor progression and correlates with clinico-pathological parameters of OSCC patients / PLoS One :e27767
Ando, S. / 1996 / Keratin 8 phosphorylation in vitro by cAMP-dependent protein kinase occurs within the amino- and carboxyl-terminal end domains / Biochem. Biophys. Res. Commun 221:67~71
Baribault, H. / 1989 / Epidermal growth factor-induced selective phosphorylation of cultured rat hepatocyte 55-kD cytokeratin before fi lament reorganization and DNA synthesis / J. Cell Biol 109:1665~1676
Beil, M. / 2003 / Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells / Nat. Cell Biol 5:803~811
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