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논문 기본 정보

자료유형
학술저널
저자정보
Park, Cana (School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University) Cho, Jae-Yong (School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University) Hwang, Bo-Mi (School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University) Hwang, In-Sok (School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University) Kim, Mi-Ran (College of Pharmacy, Chosun University) Woo, Eun-Rhan (College of Pharmacy, Chosun University) Lee, Dong-Gun (School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University)
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제18권 제4호
발행연도
2010.1
수록면
420 - 425 (6page)

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The antifungal effects and action mechanisms of styraxjaponoside A and B were investigated. Devoid of hemolytic effect, the compounds had significant effect against several human pathogenic fungal strains, with energy-independent manners. To understand the action mechanisms of the compounds, the flow cytometric analysis plotting the forward scatter and the side scatter, $DiBAC_4$(3) staining and DPH fluorescence analysis were conducted. The results indicated that the actions of the compounds were dependent upon the membrane-active mechanisms. The present study suggests that styraxjaponoside A and B exert their antimicrobial effects via membrane-disruptive mechanisms.

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