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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 411 - 416 (6page)
이용수
초록· 키워드
오류제보하기
Paclitaxel (PTX) is a effectively chemotherapeutic agent which is extensively able to treat the non-small cell lung, pancreatic, breast and other cancers. But it is a practically insoluble drug with water solubility less than $1{\mu}g/mL$, which restricts its therapeutic application. To overcome the problem, hyaluronic acid-complexed paclitaxel nanoemulsions (HPNs) were prepared by ionic complexation of paclitaxel (PTX) nanoemulsions and hyaluronic acid (HA) to specifically target non-small cell lung cancer. HPNs were composed of ${\small{DL}}-{\alpha}$-tocopheryl acetate, soybean oil, polysorbate 80, ferric chloride, and HA and fabricated by high-pressure homogenization. The HPNs were $85.2{\pm}7.55nm$ in diameter and had a zeta potential of $-35.7{\pm}0.25mV$. The encapsulation efficiency was almost 100%, and the PTX content was 3.0 mg/mL. We assessed the in vivo antitumor efficacy of the HPNs by measuring changes in tumor volume and body weight in nude mice transplanted with CD44-overexpressing NCI-H460 xenografts and treated with a bolus dose of saline, $Taxol^{(R)}$, PTX nanoemulsions (PNs), or HPNs at a dose of 25 mg/kg. Suppression of cancer cell growth was higher in the PN- and HPN-treated groups than in the $Taxol^{(R)}$ group. In particular, HPN treatment dramatically inhibited tumor growth, likely because of the specific tumor-targeting affinity of HA for CD44-overexpressed cancer cells. The loss of body weight and organ weight did not vary significantly between the groups. It is suggest that HPNs should be used to effective nanocarrier system for targeting delivery of non-small cell lung cancer overexpressing CD44 and high solubilization of poorly soluble drug.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Jong-Suep Baek / 2012 / Effect of lipid on physicochemical properties of solid lipid nanoparticle of paclitaxel / Journal of Pharmaceutical Investigation 42(5):279~283
Battistini, F. D. / 2014 / Hyaluronan as drug carrier. The in vitro efficacy and selectivity of Hyaluronan-Doxorubicin complexes to affect the viability of overexpressing CD44 receptor cells / Eur. J. Pharm. Sci 65:122~129
Danhier, F. / 2009 / Targeting of tumor endothelium by RGD-grafted PLGA-nanoparticles loaded with paclitaxel / J. Control. Release 140:166~173
Davis, M. E. / 2008 / Nanoparticle therapeutics:an emerging treatment modality for cancer / Nat. Rev. Drug Discov 7:771~782
Fang, J. / 2011 / The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect / Adv. Drug Deliv. Rev 63:136~151
Battistini, F. D. / 2014 / Hyaluronan as drug carrier. The in vitro efficacy and selectivity of Hyaluronan-Doxorubicin complexes to affect the viability of overexpressing CD44 receptor cells / Eur. J. Pharm. Sci 65:122~129
Danhier, F. / 2009 / Targeting of tumor endothelium by RGD-grafted PLGA-nanoparticles loaded with paclitaxel / J. Control. Release 140:166~173
Davis, M. E. / 2008 / Nanoparticle therapeutics:an emerging treatment modality for cancer / Nat. Rev. Drug Discov 7:771~782
Fang, J. / 2011 / The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect / Adv. Drug Deliv. Rev 63:136~151
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