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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 17 - 24 (8page)
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Histone deacetylase (HDAC) inhibitors are a promising class of anticancer agents that inhibit cancer cell growth in vitro and in vivo. Previous report has shown that apicidin inhibited SK-OV-3 cells proliferation and down-regulation of cyclin B1 and CDK1, and up-regulation of $p21^{WAF1}$ and p27. However, the mechanism of apicidin-mediated apoptotic cell death is not clearly understood. For this study, we investigated the mechanism of apoptotic pathway induced by apicidin in human ovarian cancer cell. We found that SK-OV-3 cells treated with apicidin caused an increase in the percentage of cells in the G2/M phase, which preceded apoptosis characterized by the appearance of cells with sub-G1 population. To further investigate the mechanism of apoptosis induction by apicidin, we measured TUNEL assay, poly-ADP ribose polymerase (PARP) cleavage, and caspase activity in SK-OV-3 cells treated with apicidin for 48 h. Apicidin significantly enhanced apoptosis as measured by TUNEL positive apoptotic cells, PARP cleavage, and increased Bax/Bcl-2 ratio. Induction of apoptosis was confirmed by the release of cytochrome c to cytosol. Our data suggest that apicidin-induced apoptosis in SK-OV-3 cells was accompanied by caspase-3 activation and the increase in Bax/Bcl-2 ratio. These data suggest that apicidin may be effective in the treatment of ovarian cancer through activation of intrinsic apoptotic pathway.
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참고문헌 (28)
참고문헌 신청
Ahn, M. Y. / 2008 / A natural histone deacetylase inhibitor, Psammaplin A, induces cell cycle arrest and apoptosis in human endometrial cancer cells / Gynecol. Oncol 108:27~33
American Cancer Society
Baradari, V. / 2006 / Antiproliferative and proapoptotic effects of histone deacetylase inhibitors on gastrointestinalneuroendocrine tumor cells / Endocr. Relat. Cancer 13:1237~1250
Bokelmann, I. / 2008 / Valproic acid sensitizes chronic lymphocytic leukemia cells to apoptosis and restores the balance between pro- and antiapoptotic proteins / Mol. Med 14:20~27
Cheong, J. W. / 2003 / Induction of apoptosis by apicidin, a histone deacetylase inhibitor, via the activation of mitochondria-dependent caspase cascades in human Bcr-Abl-positive leukemia cells / Clin. Cancer Res 9:5018~5027
American Cancer Society
Baradari, V. / 2006 / Antiproliferative and proapoptotic effects of histone deacetylase inhibitors on gastrointestinalneuroendocrine tumor cells / Endocr. Relat. Cancer 13:1237~1250
Bokelmann, I. / 2008 / Valproic acid sensitizes chronic lymphocytic leukemia cells to apoptosis and restores the balance between pro- and antiapoptotic proteins / Mol. Med 14:20~27
Cheong, J. W. / 2003 / Induction of apoptosis by apicidin, a histone deacetylase inhibitor, via the activation of mitochondria-dependent caspase cascades in human Bcr-Abl-positive leukemia cells / Clin. Cancer Res 9:5018~5027
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Apicidin, Histone Deacetylase Inhibitor에 의한 Human Promyelocytic U937 세포고사
Toxicological Research
2003 .09
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Differential involovement of JNK in apicidin-induced apoptosis.
대한약학회 학술대회
2002 .01
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Apoptotic potential of Apicidin and its derivatives
대한약학회 학술대회
2000 .01
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Total Synthesis of New Apicidin Derivatives as Potent Antitumor Agents
대한약학회 학술대회
2003 .01
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Apicidin Induction of cyclin E might be mediated by Spl Transcription Factor
대한약학회 학술대회
2002 .01
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Proteome Analysis of Apicidin- Treated Human Cervix Cancer Cells
대한약학회 학술대회
2002 .01
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Apicidin, a Histone Deacetylase Inhibitor, as a Potential Anticancer Agents
한국응용약물학회 추계학술발표논문집
2002 .01
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Determination of a histone deacetylase inhibitor SD-2007 by LC/MS and application to a pharmacokinetic study in rats
대한약학회 학술대회
2003 .01
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Synthesis of new Apicidin derivatives as a potential antitumor agents.
대한약학회 학술대회
2001 .01
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Apotosis Signaling of Histone Deacetylase Inhibitor, Apicidin in Human Hepatoma Cells
대한외과학회 학술대회 초록집
2005 .10
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Synthesis and Evaluation of Biological activities of New Imine Derivatives of Apicidin
대한약학회 학술대회
2002 .01
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Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells
대한약학회 학술대회
2001 .01
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Effects of histone deacetylase inhibitor, apicidin, on the p21WAF1/Cip1 gene promoter
대한약학회 학술대회
2000 .01
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Modeling of Binding Modes and Inhibition Mechanism of Apicidin Derivatives, Histone Deacetylase Inhibitors : A flexible Docking Study
대한약학회 학술대회
2002 .01
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Activation of $p21^{WAF1/Cip1}$ transcription through Sp1 sites by histone deacetylase inhibitor apicidin: Involvement of protein kinase C
대한약학회 학술대회
2001 .01
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Induction of p21WAF1/Cip1 expression via Sp1 sites by apicidin is mediated by Sp3
대한약학회 학술대회
2001 .01
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Total Synthesis of Cyclictetrapeptide Analogues of Apicidin
대한약학회 학술대회
2002 .01
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Total Synthesis of Cyclictetrapeptide Analogues of Apicidin
한국응용약물학회 추계학술발표논문집
2002 .01
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Apicidin-induced gelsolin expression via Spl sites is mediated by PKC signaling
대한약학회 학술대회
2003 .01
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$PI3K-PKC{\varepsilon}$ signaling pathway is essential for the p21WAF1/Cip1 expression by apicidin
대한약학회 학술대회
2002 .01
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