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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.9
- 수록면
- 197 - 203 (7page)
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Apicidin, a histone-deacetylase inhibitor, has been successfully used to inhibit the growth of cancer cells. In this study, the apoptotic potential and mechanistic insights of apicidin were
investigated in human myeloid leukemia U937 cells. Treatment of U937 cells with apicidin resulted in a decrease of cell viability with apoptotic characteristics, including chromatin condensation and ladderpattern fragmentation of genomic DNA. Apicidin converted the procaspase-3 protease to catalytically active effector protease, resulting in subsequent cleavage of poly (ADP-ribose) polymerase (PARP) and inhibitor of caspase-activated deoxyribonuclease (ICAD). In addition, apicidin induced the activation of caspase-9 protease and the cytosolic release of mitochondrial cytochrome c with mitochondrial membrane potential transition. Moreover, apicidin transiently increased the expression of Fas and Fas ligand proteins. Taken together, the results suggest that apicidin induces apoptosis of U937 cells through activation of intrinsic caspase cascades and Fas/FasL system with mitochondrial dysfunction.
investigated in human myeloid leukemia U937 cells. Treatment of U937 cells with apicidin resulted in a decrease of cell viability with apoptotic characteristics, including chromatin condensation and ladderpattern fragmentation of genomic DNA. Apicidin converted the procaspase-3 protease to catalytically active effector protease, resulting in subsequent cleavage of poly (ADP-ribose) polymerase (PARP) and inhibitor of caspase-activated deoxyribonuclease (ICAD). In addition, apicidin induced the activation of caspase-9 protease and the cytosolic release of mitochondrial cytochrome c with mitochondrial membrane potential transition. Moreover, apicidin transiently increased the expression of Fas and Fas ligand proteins. Taken together, the results suggest that apicidin induces apoptosis of U937 cells through activation of intrinsic caspase cascades and Fas/FasL system with mitochondrial dysfunction.
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Apicidin Induction of cyclin E might be mediated by Spl Transcription Factor
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Proteome Analysis of Apicidin- Treated Human Cervix Cancer Cells
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Apotosis Signaling of Histone Deacetylase Inhibitor, Apicidin in Human Hepatoma Cells
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Synthesis of new Apicidin derivatives as a potential antitumor agents.
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Modeling of Binding Modes and Inhibition Mechanism of Apicidin Derivatives, Histone Deacetylase Inhibitors : A flexible Docking Study
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Effects of histone deacetylase inhibitor, apicidin, on the p21WAF1/Cip1 gene promoter
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Synthesis and Evaluation of Biological activities of New Imine Derivatives of Apicidin
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Activation of $p21^{WAF1/Cip1}$ transcription through Sp1 sites by histone deacetylase inhibitor apicidin: Involvement of protein kinase C
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Total Synthesis of Cyclictetrapeptide Analogues of Apicidin
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Total Synthesis of Cyclictetrapeptide Analogues of Apicidin
한국응용약물학회 추계학술발표논문집
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Induction of p21WAF1/Cip1 expression via Sp1 sites by apicidin is mediated by Sp3
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Pharmacokinetic disposition of apicidin possessing histone deacetylase inhibiting activities
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2003 .01
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Apicidin-induced gelsolin expression via Spl sites is mediated by PKC signaling
대한약학회 학술대회
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UCI(KEPA) : I410-ECN-0101-2009-513-013745678