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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 299 - 305 (7page)
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Active cardiovascular anaphylactic response was induced in ovalbumin-sensitized, pithed Sprague-Dawley and Wistar rats. On intravenous administration of the antigen, ovalbumin, marked tachycardia and pressor responses were immediately elicited. Thereafter, a delayed long-lasting severe hypotensive response was observed. These anaphylactic cardiovascular responses were maximal 2-3 weeks after the sensitization, and the response was slightly diminished 6 weeks after sensitization. The immediate pressor response was blocked by a non-selective serotonin antagonist methysergide at a dose-dependent manner, but not by histamine receptor antagonists mepyramine (pyrilamine) or cimetidine. The delayed hypotension was reduced either by histamine $H_1$ receptor antagonist mepyramine or $H_2$ receptor antagonist cimetidine, both in a dose-dependent manner. The tachycardic response was not influenced by serotonin or histamine receptor antagonists examined in this study. Differently from the cardiovascular responses, there was no observable bronchial contraction in Sprague-Dawley rat trachea in contrast to Wistar rat where the trachea contracted to in vitro antigen challenge. The cardiovascular anaphylactic model seems to be useful for studying cardiovascular events that occur exclusively in peripheral heart-blood vessel systems. The involvement of two major anaphylactic mediators, serotonin and histamine, is partially demonstrated.
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참고문헌 (22)
참고문헌 신청
Bartlett,L.A / 1963 / The action of histamine on the isolated heart / Brit. J. Pharmacol. Chemother 21:450~461
Church,M.K / 1975 / Response of rat lung to humoral mediators of anaphylaxis and its modification by drugs and sensitization / Br. J. Pharmacol 55:423~430
El-Shanawany T / 2008 / Clinical immunology review series: an approach to the patient with anaphylaxis / Clin. Exp. Immunol 153:1~9
Farmer J. B / 1975 / Mediators of passive lung anaphylaxis in the rat / Brit. J. Pharmacol 55:57~64
Frodi, G / 2008 / 5-HT1B receptor subtype and aging rat blood vessels / Pharmacology 81:70~78
Church,M.K / 1975 / Response of rat lung to humoral mediators of anaphylaxis and its modification by drugs and sensitization / Br. J. Pharmacol 55:423~430
El-Shanawany T / 2008 / Clinical immunology review series: an approach to the patient with anaphylaxis / Clin. Exp. Immunol 153:1~9
Farmer J. B / 1975 / Mediators of passive lung anaphylaxis in the rat / Brit. J. Pharmacol 55:57~64
Frodi, G / 2008 / 5-HT1B receptor subtype and aging rat blood vessels / Pharmacology 81:70~78
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