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자료유형
학술저널
저자정보
Kim, Kyu Won (Department of Pediatrics, Gachon University Gil Medical Center) Sung, Jae Jin (Department of Pediatrics, Gachon University Gil Medical Center) Tchah, Hann (Department of Pediatrics, Gachon University Gil Medical Center) Ryoo, Eell (Department of Pediatrics, Gachon University Gil Medical Center) Cho, Hye Kyung (Department of Pediatrics, Gachon University Gil Medical Center) Sun, Yong Han (Department of Pediatrics, Gachon University Gil Medical Center) Cho, Kang Ho (Department of Pediatrics, Gachon University Gil Medical Center) Son, Dong Woo (Department of Pediatrics, Gachon University Gil Medical Center) Jeon, In Sang (Department of Pediatrics, Gachon University Gil Medical Center) Kim, Yun Mi (Department of Nursing, Gachon University)
저널정보
대한소아청소년과학회 Clinical and Experimental Pediatrics Korean journal of pediatrics 제58권 제6호
발행연도
2015.1
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211 - 217 (7page)

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Purpose: Mycoplasma pneumoniae (MP) infection is a major cause of respiratory infection in school-aged children. Extrapulmonary manifestations of MP infection are common, but liver involvement has been rarely reported. The aim of this study was to determine the clinical characteristics of MP-associated hepatitis. Methods: This prospective study included 1,044 pediatric patients with MP infection diagnosed serologically with MP IgM at one medical center from January 2006 to December 2012. Eighty of these patients had elevated levels of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT), each greater than 50 IU/L, without any other specific liver disorder and were compared with the 964 children without liver disorders. Results: In total, 7.7% of patients with MP infection had a diagnosis of hepatitis, especially in fall and winter. The ratio of male to female patients was 1.7:1, and the mean age of the patients was 5 years and 5 months. The most common symptoms were cough, fever, and sputum. Anorexia was the most common gastrointestinal symptom, followed by nausea/vomiting, diarrhea, and abdominal pain. Mean levels of AST and ALT were 100.65 IU/L and 118.73 IU/L, respectively. Serum AST/ALT level was normalized within 7.5 days on average without complications. The mean duration of hospitalization (11.3 days) was longer for children with hepatitis than for those without hepatitis (P=0.034). Conclusion: MP-associated hepatitis is not uncommon and has a relatively good prognosis. Therefore, clinicians should be concerned about liver involvement in MP infection but avoid further unnecessary evaluation of hepatitis associated with MP.

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