Heparanase mRNA and Protein Expression Correlates with Clinicopathologic Features of Gastric Cancer Patients: a Meta-analysis

Li, Hai-Long; Gu, Jing; Wu, Jian-Jun; Ma, Chun-Lin; Yang, Ya-Li; Wang, Hu-Ping; Wang, Jing; Wang, Yong; Chen, Che; Wu, Hong-Yan

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자료유형: 학술저널

저자정보: Li, Hai-Long (School of Medicine Technology, Gansu University of Traditional Chinese Medicine) Gu, Jing (Key Laboratory of Traditional Chinese Herbs and Prescription Innovation and Transformation of Gansu Province, Gansu University of Traditional Chinese Medicine) Wu, Jian-Jun (School of Public Health Institute, Gansu University of Traditional Chinese Medicine) Ma, Chun-Lin (Key Laboratory of Traditional Chinese Herbs and Prescription Innovation and Transformation of Gansu Province, Gansu University of Traditional Chinese Medicine) Yang, Ya-Li (School of Medicine Technology, Gansu University of Traditional Chinese Medicine) Wang, Hu-Ping (Key Laboratory of Traditional Chinese Herbs and Prescription Innovation and Transformation of Gansu Province, Gansu University of Traditional Chinese Medicine) Wang, Jing (School of Medicine Technology, Gansu University of Traditional Chinese Medicine) Wang, Yong (School of Medicine Technology, Gansu University of Traditional Chinese Medicine) Chen, Che (School of Medicine Technology, Gansu University of Traditional Chinese Medicine) Wu, Hong-Yan (Key Laboratory of Tra)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제18호

발행연도: 2015.1

수록면: 8,653 - 8,658 (6page)

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Background: Heparanase is believed to be involved in gastric carcinogenesis. However, the clinicopathologic features of gastric cancer with high heparanase expression remain unclear. Aim : The purpose of this study was to comprehensively and quantitatively summarize available evidence for the use of heparanase mRNA and protein expression to evaluate the clinicopathological associations in gastric cancer in Asian patients by meta-analysis. Materials and Methods: Relevant articles listed in MEDLINE, CNKI and the Cochrane Library databases up to MARCH 2015 were searched by use of several keywords in electronic databases. A meta-analysis was performed to clarify the impact of heparanase mRNA and protein on clinicopathological parameters in gastric cancer. Combined ORs with 95%CIs were calculated by Revman 5.0, and publication bias testing was performed by stata12.0. Results: A total of 27 studies which included 3,891 gastric cancer patients were combined in the final analysis. When stratifying the studies by the pathological variables of heparanase mRNA expression, the depth of invasion (633 patients) (OR=4.96; 95% CI=2.38-1.37; P<0.0001), lymph node metastasis (639 patients) (OR=6.22; 95%CI=2.70-14.34, P<0.0001), and lymph node metastasis (383 patients) (OR=6.85; 95% CI=2.04-23.04; P=0.002) were all significant. When stratifying the studies by the pathological variables of heparanase protein expression, this was the case for depth of invasion (1250 patients) (OR=2.76; 95% CI=1.52-5.03; P=0.0009), lymph node metastasis (1178 patients) (OR=4.79 ; 95% CI=3.37-6.80, P<0.00001), tumor size (727 patients) (OR=2.06 ; 95% CI=1.31-3.23; P=0.002) (OR=2.61; 95% CI=2.09-3.27; P=0.000), and TNM stage (1233 patients) (OR=6.85; 95% CI=2.04-23.04; P=0.002). Egger's tests suggested publication bias for depth of invasion, lymph node metastasis, lymph node metastasis and tumor size of heparanase mRNA and protein expression. Conclusions: This meta-analysis suggests that higher heparanase expression in gastric cancer is associated with clinicopathologic features of depth of invasion, lymph node metastasis and TNM stage at mRNA and protein levels, and of tumor size only at the protein level. Egger's tests suggested publication bias for these clinicopathologic features of heparanase mRNA and protein expression, and which may be caused by shortage of relevant studies. As a result, although abundant reports showed heparanase may be associated with clinicopathologic features in gastric cancer, this meta-analysis indicates that more strict studies were needed to evaluate its clinicopathologic significance.

#Gastric cancer #heparanase #clinicopathologic features #meta-analysis

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Li, Hai-Long

소속기관 Department of Clinical Testing Teaching and Research, School of Medical Technology, Gansu Traditiona