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논문 기본 정보

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학술저널
저자정보
Kim, Soo Jeong (Departments of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) Yi, Hyun Kyung (Departments of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) Lim, Chae Hong (Departments of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) Cho, Young Seok (Departments of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) Choi, Joon Young (Departments of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) Choe, Yearn Seong (Departments of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) Lee, Kyung-Han (Departments of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) Kim, Byung-Tae (Departments of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) Moon, Seung Hwan (Departments of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
저널정보
대한핵의학회 Nuclear medicine and molecular imaging : NMMI Nuclear medicine and molecular imaging : NMMI 제50권 제4호
발행연도
2016.1
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300 - 307 (8page)

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Purpose $^{18}F$-fluorodeoxyglucose (FDG) PET/CT is useful for staging and evaluating treatment response in patients with diffuse large B-cell lymphoma (DLBCL). A five-point scale model using the mediastinal blood pool (MBP) and liver as references is a recommended method for interpreting treatment response. We evaluated the variability in standardized uptake values (SUVs) of the MBP, liver, and myocardium during chemotherapy in patients with DLBCL. Methods We analyzed 60 patients with DLBCL who received rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) treatment and underwent baseline, interim, and final FDG PET/CT scans. The FDG uptakes of lymphoma lesions, MBP, liver, and myocardium were assessed, and changes in the MBP and liver SUV and possible associated factors were evaluated. Results The SUV of the liver did not change significantly during the chemotherapy. However, the $SUV_{mean}$ of MBP showed a significant change though the difference was small (p = 0.019). $SUV_{mean}$ of MBP and liver at baseline and interim scans was significantly lower in patients with advanced Ann Arbor stage on diagnosis. The $SUV_{mean}$ of the MBP and liver was negatively correlated with the volumetric index of lymphoma lesions in baseline scans (r = -0.547, p < 0.001; r = -0.502, p < 0.001). Positive myocardial FDG uptake was more frequently observed in interim and final scans than in the baseline scan, but there was no significant association between the MBP and liver uptake and myocardial uptake. Conclusions The SUV of the liver was not significantly changed during R-CHOP chemotherapy in patients with DLBCL, whereas the MBP SUVof the interim scan decreased slightly. However, the SUV of the reference organs may be affected by tumor burden, and this should be considered when assessing follow-up scans. Although myocardial FDG uptake was more frequently observed after R-CHOP chemotherapy, it did not affect the SUV of the MBP and liver.
#Diffuse large B-cell lymphoma #FDG #PET #Mediastinum #Liver #Myocardium

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참고문헌 (15)

참고문헌 신청
Martelli M / 2013 / Diffuse large B-cell lymphoma / Crit Rev Oncol Hematol 87:146~171 google schola National Comprehensive Cancer Network / Non-Hodkin’s lymphomas (Version 2.2015) google schola Ceriani L / 2012 / 18F-FDG uptake changes in liver and mediastinum during chemotherapy in patients with diffuse large B-cell lymphoma / Clin Nucl Med 37:949~952 google schola Chiaravalloti A / 2014 / Factors affecting intrapatient liver and mediastinal blood pool(1)(8)F-FDG standardized uptake value changes during ABVD chemotherapy in Hodgkin’s lymphoma / Eur J Nucl Med Mol Imaging 41:1123~1132 google schola Kaya B / 2015 / Clin Imaging: Effect of R-CHOP chemotherapy on liver and mediastinal blood pool F-FDG standardized uptake values in patients with non-Hodgkin’s lymphoma google schola

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