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논문 기본 정보

자료유형
학술저널
저자정보
Kim, Min Hwan (Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences [KIRAMS]) Lee, Yong Jin (Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences [KIRAMS]) Kang, Joo Hyun (Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences [KIRAMS])
저널정보
대한핵의학회 Nuclear medicine and molecular imaging : NMMI Nuclear medicine and molecular imaging : NMMI 제50권 제4호
발행연도
2016.1
수록면
275 - 283 (9page)

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The molecular imaging techniques allow monitoring of the transplanted cells in the same individuals over time, from early localization to the survival, migration, and differentiation. Generally, there are two methods of stem cell labeling: direct and indirect labeling methods. The direct labeling method introduces a labeling agent into the cell, which is stably incorporated or attached to the cells prior to transplantation. Direct labeling of cells with radionuclides is a simple method with relatively fewer adverse events related to genetic responses. However, it can only allow short-term distribution of transplanted cells because of the decreasing imaging signal with radiodecay, according to the physical half-lives, or the signal becomes more diffuse with cell division and dispersion. The indirect labeling method is based on the expression of a reporter gene transduced into the cell before transplantation, which is then visualized upon the injection of an appropriate probe or substrate. In this review, various imaging strategies to monitor the survival and behavior change of transplanted stem cells are covered. Taking these new approaches together, the direct and indirect labeling methods may provide new insights on the roles of in vivo stem cell monitoring, from bench to bedside.

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