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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 390 - 395 (6page)
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The present study investigated the sedative effects of Sophora flavescens (SF) and its bioactive compound, matrine through performing locomotor activity test and the electroencephalography (EEG) analysis in the rat. The underlying neural mechanism of their beneficial effects was determined by assessing c-Fos immunoreactivity and serotonin (5-HT) in the brain utilizing immunohistochemical method and enzyme-linked immunosorbent assay. The results showed that SF and matrine administration had an effect on normalization of caffeine-induced hyperactivity and promoting a shift toward non-rapid eye movement (NREM) sleep. c-Fos-immunoreactivity and 5-HT level in the ventrolateral preoptic nucleus (VLPO), a sleep promoting region, were increased in the both SF and matrine-injected groups. In conclusion, SF and its bioactive compound, matrine alleviated caffeine-induced hyperactivity and promoted NREM sleep by activating VLPO neurons and modulating serotonergic transmission. It is suggested that SF might be a useful natural alternatives for hypnotic medicine.
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참고문헌 (31)
참고문헌 신청
Abdollahnejad, F. / 2016 / Investigation of sedative and hypnotic effects of Amygdalus communis L. extract: behavioral assessments and EEG studies on rat / J. Nat. Med 70:190~197
Alfajaro, M. M. / 2014 / Anti-rotavirus effects by combination therapy of stevioside and Sophora flavescens extract / Res. Vet. Sci 96:567~575
Bjorvatn, B. / 2002 / Effects of sleep deprivation on extracellular serotonin in hippocampus and frontal cortex of the rat / Neuroscience 113:323~330
Bravo, R. / 2013 / Tryptophan-enriched cereal intake improves nocturnal sleep, melatonin, serotonin, and total antioxidant capacity levels and mood in elderly humans / Age (Dordr.) 35:1277~1285
Ferre, S. / 2008 / An update on the mechanisms of the psychostimulant effects of caffeine / J. Neurochem 105:1067~1079
Alfajaro, M. M. / 2014 / Anti-rotavirus effects by combination therapy of stevioside and Sophora flavescens extract / Res. Vet. Sci 96:567~575
Bjorvatn, B. / 2002 / Effects of sleep deprivation on extracellular serotonin in hippocampus and frontal cortex of the rat / Neuroscience 113:323~330
Bravo, R. / 2013 / Tryptophan-enriched cereal intake improves nocturnal sleep, melatonin, serotonin, and total antioxidant capacity levels and mood in elderly humans / Age (Dordr.) 35:1277~1285
Ferre, S. / 2008 / An update on the mechanisms of the psychostimulant effects of caffeine / J. Neurochem 105:1067~1079
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