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Biodegradable block copolymer of poly(L-lactic acid-block-${\gamma}$-aminobutyric acid) were synthesized for the controlled release of ${\gamma}$-aminobutyric acid (GABA), a neurotransmitter. Poly(L-lactic acid-block-${\gamma}$-aminobutyric acid) was prepared by the self-initiative polymerization of 2-pyrrolidone at the activated end group of poly(L-lactic acid), which was substituted with dehydrated 2-pyrrolidone. The molecular structure of the block copolymer was analyzed by FT-IR spectroscopy, 1H NMR spectroscopy, and XRD. The surface energies and biodegradabilities of the block copolymers were tested. The release behavior of GABA from the block copolymer matrices was investigated. The relative quantity of the blocks had an accommodative amplitude in the release of GABA.
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참고문헌 (23)
참고문헌 신청
I. F. Uchegbu. / 2006 / Polymers in Drug Delivery / Taylor & Francis :35~62
A. Kumari. / 2010 / Biodegradable Polymeric Nanoparticles Based Drug Delivery Systems / Colloids Surf B : Biointerfaces 75:1~18
M. Gupta. / 2011 / Targeted Drug Delivery System : a Review / Res. J. Chem. Sci 1:135~138
A. J. R. Lasprilla. / 2012 / Poly-Lactic Acid Synthesis for Application in Biomedical Devices-a Review / Biotechnol. Adv 30:321~328
K. Yasugi. / 1999 / Preparation and Characterization of Polymer Micelles from Poly(Ethylene Glycol)-Poly(D, L-Lactide)Block Copolymers as Potential Drug Carrier / J. Control Release 62:89~100
A. Kumari. / 2010 / Biodegradable Polymeric Nanoparticles Based Drug Delivery Systems / Colloids Surf B : Biointerfaces 75:1~18
M. Gupta. / 2011 / Targeted Drug Delivery System : a Review / Res. J. Chem. Sci 1:135~138
A. J. R. Lasprilla. / 2012 / Poly-Lactic Acid Synthesis for Application in Biomedical Devices-a Review / Biotechnol. Adv 30:321~328
K. Yasugi. / 1999 / Preparation and Characterization of Polymer Micelles from Poly(Ethylene Glycol)-Poly(D, L-Lactide)Block Copolymers as Potential Drug Carrier / J. Control Release 62:89~100
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