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Effects of Curcumae Longae Rhizoma Pharmacopuncture on Monosodium Iodoacetate-induced Osteoarthritis Rats
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강황(薑黃) 약침이 Monosodium Iodoacetate 유도 골관절염 흰쥐에 미치는 영향

논문 기본 정보

Type
Academic journal
Author
Lee, Jong-Hoon (대구한의대학교 한의과대학 한방재활의학과교실) Woo, Chang-Hoon (대구한의대학교 한의과대학 한방재활의학과교실)
Journal
The Korean Academy Of Oriental Rehabilitation Medicine 한방재활의학과학회지 한방재활의학과학회지 제29권 제2호 KCI Accredited Journals
Published
2019.1
Pages
115 - 133 (19page)

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Effects of Curcumae Longae Rhizoma Pharmacopuncture on Monosodium Iodoacetate-induced Osteoarthritis Rats
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Research history (4)

2019

Effects of Curcumae Longae Rhizoma Pharmacopuncture on Monosodium Iodoacetate-induced Osteoarthritis Rats
Lee ,  Jong-Hoon ,  Woo 한방재활의학과학회지 2019.01 Academic journal

2018

이종훈 韓醫學科 韓方再活醫學科 2018.01 Thesis

2016

Effects of Seungseup-tang on MIA-induced Osteoarthritis Rats
이종훈 한의 2016.01 Thesis
Effects of Seungseup-tang on MIA-induced Osteoarthritis Rats
Lee ,  Jong-Hoon ,  Woo and others 5 한방재활의학과학회지 2016.01 Academic journal
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Abstract· Keywords

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Objectives The purpose of this study was to evaluate the effects of Curcumae Longae Rhizoma pharmacopuncture on the monosodium iodoacetate (MIA)-induced osteoarthritis rats. Methods Osteoarthritis was induced by injection of MIA ($50{\mu}L$ with 80 mg/mL) into knee joint cavity of rats. Rats were divided into 6 groups. Normal group was injected by normal saline into knee joint cavity only. Control group was induced for osteoarthritis by MIA and orally administered with distilled water. Normal Saline group was induced for osteoarthritis by MIA and injected with normal saline $100{\mu}L$. Positive comparison group was injected with MIA and orally administered with indomethacin 5 mg/kg. Curcumae Longae Rhizoma pharmacopuncture low concentration (CL) group was induced for osteoarthritis by MIA and injected with Curcumae Longae Rhizoma pharmacopuncture low concentration $100{\mu}L$. Curcumae Longae Rhizoma pharmacopuncture high concentration (CH) group was induced for osteoarthritis by MIA and injected with Curcumae Longae Rhizoma pharmacopuncture high concentration $100{\mu}L$. Curcumae Longae Rhizoma pharmacopuncture was injected at ST35 and EX-LE4 each group (CL, CH). After that, hind paw weight distribution was measured and oxidative stress biomarker in serum, liver function biomarker in serum, western blot analysis were measured. Histological analysis of knee joint tissue was performed by hematoxylin and eosin staining, Safranin-O staining and Masson's trichrome staining. Results Hind paw weight distribution was significantly improved in both group. alanine aminotransferanse and aspartate aminotransferase were decreased significantly in CH group compare with Indomethacin threated group. Antioxidant enzyme glutathione peroxidase, Catalase and heme oxygenase-1 were increased in CH group compare with control group. Inflammatory cytokine cyclooxygenase-2, inducible nitric oxide synthase and interleukin-1 beta were decreased significantly in CH group. Histological analysis result shows that protective effects of joint and cartilage were observed in both CH and CL groups in a concentration-dependent. Conclusions The result suggest that Curcumae Longae Rhizoma pharmacopuncture has anti-oxidation effect, anti-inflammatory effect and also can prevent progression of osteoarthritis and protect joint cartilage.
#Curcumae Longae Rhizoma pharmacopuncture #Osteoarthritis #Anti-oxidation #Anti-inflammation #Monosodium iodoacetate #MIA)

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References (56)

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The Society of Korean Medicine Rehabilitation / 2015 / Korea Rehabilitation Medicine / Koonja Publishing :102~116 google schola The Korean Orthopaedic Association / 2013 / Orthopaedics / Choisin medical Publishing Co :49~326 google schola 구지향 / 2017 / 무릎 골관절염의 봉독 약침 치료에 대한 체계적 문헌 고찰 / 한방재활의학과학회지 27(3):47~60 dbpia Science Commitee of Korean Pharmacopuncture Institute, Pharmacopuncture Medicine Labaratory / 2011 / Pharmacopuncturology / Elsevier Korea :3~8 google schola A Herbal Medicine Compilation Committee of a College of Korean Medicine / 2014 / Herbal medicine / Yeonglimsa :454~456 google schola

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