Prognostic Factor of Laryngeal Papillomatosis: 20 Years Experience

정은재; 홍석진; 조재구; 백승국; 우정수; 권순영; 정광윤

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자료유형: 학술저널

저자정보: 정은재 (한림대학교 의과대학 이비인후-두경부외과학교실, 일송두경부암센터) 홍석진 (고려대학교 의과대학 이비인후-두경부외과학교실) 조재구 (고려대학교 의과대학 이비인후-두경부외과학교실) 백승국 (고려대학교 의과대학 이비인후-두경부외과학교실) 우정수 (고려대학교 의과대학 이비인후-두경부외과학교실) 권순영 (고려대학교 의과대학 이비인후-두경부외과학교실) 정광윤 (고려대학교 의과대학 이비인후-두경부외과학교실)

저널정보: 대한기관식도과학회 대한기관식도과학회지 대한기관식도과학회지 제16권 제2호

발행연도: 2010.1

수록면: 145 - 148 (4page)

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Background: Laryngeal papillomatosis, which is cased by human papillomavirus, is the most common benign neoplasm of the larynx. However, the prognosis of this disease remains really unpredictable. The aim of this paper is to determine whether any clinical features at the time of diagnosis could predict its course. Material and Method: Eighty-six patients treated at our institution during the last 20 years were analyzed retrospectively. All patients had microsurgery under general anesthesia. All patients' follow-up period was more than 1 year. We divided the patients into 1) Juvenile versus adult group based on their age 20, 2) single surgical method with laser versus dual surgical method with laser and microdebrider group, and 3) single subsite versus multiple subsites group. And we compared the therapeutic outcome. Results: The recurrence rate was 100% (15 patients) in the JP group and 56% (40 patients) in the AP group. Juvenile versus adult group was the only independent prognostic factor by univariate, and multivariate analysis. Microdebrider resection technique and multiple subsites were not associated with treatment result. Time period from the first surgery to recurrence detection was different statistically only for the age group. The number of surgery in the JP group ranged from 1 to 31 (mean 8.8). In the AP group the number of surgery ranged from 1 to 25 (mean 3.7). It was statistically different. Conclusion: Prognosis for the laryngeal papillomatosis remains unpredictable. Only patients' age was the only independent prognostic factor.

#Larynx #Papillomatosis #Prognosis

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