재발성 호흡기 유두종증의 임상양상과 중합효소반응을 이용한 유두종 바이러스의 검출

왕수건; 이병주; 전경명; 고의경; 안회영; 공수근

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자료유형: 학술저널

저자정보: 왕수건 이병주 전경명 고의경 안회영 공수근

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제45권 제1호

발행연도: 2002.1

수록면: 69 - 75 (7page)

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연구방법

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Background and Objectives：Recurrent laryngeal papillomatosis (RRP) have been divided into juvenile or aggresive forms, and adult or non-agresive forms. This study attempted to characterize these two forms of RRP in our series and to detect human papilloma virus (HPV) using polymerase chain reaction (PCR). Materials and Method：Authors reviewed the re-cords of 60 patients treated for RRP over a 16-year period from 1983 to 1999 at the Department of otolaryngology, Pusan state, number of operation, agressivenes, outcome of treatment and complications after operation. Twenty-thre parafine-mbedded tissues were selected to PCR using type-specific primer pairs. Results：1) Subglottic extension, tracheotomy, time of operation and agresivenes were more comon in juvenile form than the adult form. 2) The multiple type was also co-mon in the adult form. 3) Non-agresive and single types showed better response for treatment. 4) There are no signifi-cant differences of cure rate acording to age and treatment modality, but preoperative α-interferon therapy showed more effective in the case of compromised airway. 5) HPV type 6, 11 in 10 cases (43.5 %) were detected out of 23 cases. Most detected cases were non-improvement group. Conclusion：The significant difference of treatment results are found in com-parison betwen agresive and non-agresive forms and α-interferon may be an effective therapy for aggressive respira-tory papillomatosis. HPV subtype may be related to the prognosis factor. (Korean J Otolaryngol 2002;45:69-75)

#재발성 호흡기 유두종증·유두종바이러스·중합효소반응. #Recurrent respiratory papillomatosis #RRP)· HPV· PCR.

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