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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 87 - 91 (5page)
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초록· 키워드
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Objectives : In order to confirm whether extracts of different parts of Zostera marina (ZM), a marine flowering plant, can be used as cosmetic ingredients, this study evaluated their cytotoxicity and cytoprotective effects against ultraviolet B (UVB). Inflammatory responses induced by UV stimuli are also associated with the aging of the skin.Methods : We investigated the effects of ZM extracts on cells through the water soluble tetrazolium salt-1(WST-1) assay for cell viability. In order to investigate the anti-inflammatory effects, we evaluated the suppression of Cyclooxygenase-2 (COX-2) expression by ZM extracts in HaCaT cells with UVB-induced damages, and also evaluated the production of Prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) in RAW 264.7 cells with LPS-induced damages.Results : High cell viabilities above 90% were observed in all types of ZM extracts, except for whole ZM extract at 0.5 mg/ml; in keratinocytes with UVB-induced damages, the cell viabilities were above 80% when treated with all types of ZM extracts. We confirmed their anti-inflammatory effects by investigating the suppression of inflammatory mediators. In keratinocytes with UVB-induced damages, COX-2 expression decreased in the experimental group treated with ZM extract. Similarly, in RAW 264.7 cells where inflammation was induced with LPS, the biosynthesis of PGE<sub>2</sub> was inhibited.Conclusion : These results suggest that ethanol extracts from Zostera marina may have value as the potential anti-inflammatory medicinal plant. Also based on the abovementioned results, ZM extract protects skin cells from UV-induced damages, and thus can be used in topically applied products for skin protection.
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참고문헌 (14)
참고문헌 신청
이해준 / 2012 / 자외선 유도 피부주름 및 암발생에 대한 누에동충하초(Paecilomyces japonica)의 보호효과 평가 / 방사선방어학회지 37(1):50~55
Ansel J / 1988 / The expression and modulation of IL-1 alpha in murine keratinocytes / J. Immunol 140:2274~2278
Halliday GM / 2005 / Inflammation, gene mutation and photoimmunosuppression in response to UVR induced oxidative damage contributes to photocarcinogenesis / Mutation Research 571:107~120
Bodet C / 2006 / Anti-inflammatory Activity of a High-molecular-weight Cranberry Fraction on Macrophages Stimulated by Lipopolysaccharides from Periodontopathogens / Journal of dental research 85:235~239
Lee SH / 1992 / Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide / The Journal of Biological Chemistry 267:25934~25938
Ansel J / 1988 / The expression and modulation of IL-1 alpha in murine keratinocytes / J. Immunol 140:2274~2278
Halliday GM / 2005 / Inflammation, gene mutation and photoimmunosuppression in response to UVR induced oxidative damage contributes to photocarcinogenesis / Mutation Research 571:107~120
Bodet C / 2006 / Anti-inflammatory Activity of a High-molecular-weight Cranberry Fraction on Macrophages Stimulated by Lipopolysaccharides from Periodontopathogens / Journal of dental research 85:235~239
Lee SH / 1992 / Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide / The Journal of Biological Chemistry 267:25934~25938
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