지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Prunellae Spica, the herbaceous plant in the genus Prunella, is a traditional herbal medicine and has been reported to have diuretic, anti-bacterial and anti-oxidant effects. However, the mechanism of its action was not clearly identified. In the present study, we investigated the hepatoprotective effect of Prunellae Spica extract (PSE) against the damage of mitochondria and death in hepatocyte induced by oxidative stress. Treatment of arachidonic acid (AA)+iron significantly induced oxidative stress and apoptosis in the hepatocytes. However, PSE protected cells and inhibited apoptosis by altering the protein levels such as poly(ADP-ribose) polymerase and pro-caspase 3. Moreover, AA+iron induced reactive oxygen species production and mitochondrial dysfunction, and Both of them were inhibited by PSE treatment. PSE markedly activated AMP-activated protein kinase (AMPK), an important regulator in cell survival. Furthermore, this activation by PSE was mediated with liver kinase B1, a major upstream kinase that phosphorylates Thr 172 of AMPKα, and this activation was associated with its cell protection, as assessed by an experiment of a chemical inhibitor. In conclusion, this study demonstrate that PSE protects hepatocytes against oxidative stress as mediated with activation of LKB1-dependent AMPK pathway.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
夏枯草의 간세포에서 항산화 및 미토콘드리아 보호효과
동의생리병리학회지
2016 .02
-
삼릉(三稜) 추출물의 간세포 보호 및 미토콘드리아 보호 효과
대한한의학방제학회지
2015 .01
-
Is Partial Splenic Embolization a Good Option to Prevent Cirrhotic Complications in the Long Term?
Journal of Korean Medical Science
2019 .01
-
AMPK 활성화를 통한 목통의 항산화 효과
동의생리병리학회지
2015 .02
-
AMPK 활성화를 통한 목통의 항산화 효과
동의생리병리학회지
2015 .01
-
Long-Term Efficacy and Safety of Partial Splenic Embolization in Hepatocellular Carcinoma Patients with Thrombocytopenia Who Underwent Transarterial Chemoembolization
Journal of Korean Medical Science
2019 .01
-
20S-Protopanaxadiol, an aglycosylated ginsenoside metabolite, induces hepatic stellate cell apoptosis through liver kinase B1-AMP-activated protein kinase activation
Journal of Ginseng Research
2017 .07
-
Role of AMP-Activated Protein Kinase (AMPK) in Smoking-Induced Lung Inflammation and Emphysema
Tuberculosis and Respiratory Diseases
2015 .01
-
Metformin Ameliorates Lipotoxic β-Cell Dysfunction through a Concentration-Dependent Dual Mechanism of Action
Diabetes and Metabolism Journal
2019 .01
-
아라키돈산과 철 유도성 산화적 스트레스에 대한 금앵자(金櫻子) 열수 추출물의 간세포 보호 효능
대한본초학회지(본초분과학회지)
2015 .01
-
Is 5´-AMP-Activated Protein Kinase Both Jekyll and Hyde in Bladder Cancer?
International Neurourology Journal
2015 .01
-
Effects of Different Bandaging Methods for Treating Patients With Breast Cancer-Related Lymphedema
Annals of Rehabilitation Medicine
2019 .01
-
HepG2 세포에서 AMPK 활성화를 통한 호나복(胡蘿蔔) 에탄올 추출물의 간 세포 보호 효과
대한한의학방제학회지
2018 .01
-
？角刺 추출물의 Nrf2 활성화를 통한 간세포 보호 효과
대한본초학회지(본초분과학회지)
2015 .01
-
Quercetin-induced apoptosis ameliorates vascular smooth muscle cell senescence through AMP-activated protein kinase signaling pathway
The Korean Journal of Physiology & Pharmacology
2020 .01
-
하고초추출물의 갑상선기능항진증 랫트모델에서의 한열조절작용에 의한 개선효능 연구
대한본초학회지(본초분과학회지)
2018 .01
-
Reserpine treatment activates AMP activated protein kinase (AMPK)
Natural Product Sciences
2017 .09
-
Regulation of exercise-stimulated glucose uptake in skeletal muscle
Annals of Pediatirc Endocrinology & Metabolism
2016 .01
-
Three-dimensional (3D) printing of mouse primary hepatocytes to generate 3D hepatic structure
Annals of Surgical Treatment and Research
2017 .02
-
Implications of oxidative stress in chronic kidney disease: a review on current concepts and therapies
Kidney Research and Clinical Practice
2021 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0