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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives Angiotensin-converting enzyme (ACE) gene and plasma levels of cytokines, such as tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$), interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-10 (IL-10), have previously been determined to be associated with depression. The purpose of this study was to investigate the association of plasma levels of ACE and cytokines with recurrent depression. Methods A total of 52 participants (14 male, 38 female, aged $43.9{\pm}14.0years$) were enrolled after being diagnosed with depression by experienced psychiatrists using the Mini International Neuropsychiatric Interview from the outpatient clinic of the Department of Psychiatry, CHA Bundang Medical Center. The participants completed blood sampling, the Hamilton Depression Rating Scale (HAMD), the Beck Depression Inventory, the Beck Anxiety Inventory, and the Scale for Suicidal Ideation. Results ACE plasma levels are higher in patients with recurrent depression ($27.4{\pm}10.4U/L$) than in patients with newly diagnosed depression ($19.1{\pm}7.7U/L$) (p = 0.004). The levels of cytokines, such as $TNF-{\alpha}$, IL-4, IL-6, IL-10, are not significantly different between the two groups. Additionally, the ACE plasma level is negatively correlated with a reduction in the HAMD over six weeks (r = -0.429, p = 0.046, n = 22). Conclusions The current findings show that plasma ACE levels may be associated with recurrent depression and further suggest that the renin-angiotensin system could play a role in recurrent depression.
목차
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참고문헌 (43)
참고문헌 신청
Nutt DJ / 2008 / Relationship of neurotransmitters to the symptoms of major depressive disorder / J Clin Psychiatry 69(E1):4~7
Ancelin ML / 2013 / Angiotensin-converting enzyme gene variants are associated with both cortisol secretion and late-life depression / Transl Psychiatry 3:e322
Armando I / 2007 / Angiotensin II AT1receptor blockade prevents the hypothalamic corticotropin-releasing factor response to isolation stress / Brain Res 1142:92~99
Arinami T / 1996 / An insertion/deletion polymorphism in the angiotensin converting enzyme gene is associated with both brain substance P contents and affective disorders / Biol Psychiatry 40:1122~1127
Hui L / 2015 / Association of angiotensin-converting enzyme gene polymorphism with schizophrenia and depressive symptom severity in a Chinese population / Hum Psychopharmacol 30:100~107
Ancelin ML / 2013 / Angiotensin-converting enzyme gene variants are associated with both cortisol secretion and late-life depression / Transl Psychiatry 3:e322
Armando I / 2007 / Angiotensin II AT1receptor blockade prevents the hypothalamic corticotropin-releasing factor response to isolation stress / Brain Res 1142:92~99
Arinami T / 1996 / An insertion/deletion polymorphism in the angiotensin converting enzyme gene is associated with both brain substance P contents and affective disorders / Biol Psychiatry 40:1122~1127
Hui L / 2015 / Association of angiotensin-converting enzyme gene polymorphism with schizophrenia and depressive symptom severity in a Chinese population / Hum Psychopharmacol 30:100~107
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