지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives This study was conducted to investigate the possibility of neurological soft signs as an endophenotype for schizophrenia by examining neurological soft signs in patients, their unaffected siblings and normal comparison subjects. Methods The study sample consisted of 32 patients, 25 of their unaffected siblings and 30 normal comparison subjects. Neurological soft signs were evaluated using the Cambridge Neurological Inventory Part 2. soft sign assessment. Results The patients were significantly more impaired than normal comparison subjects (p = 0.047) on primitive reflex. The patients were significantly more impaired than siblings (p = 0.004) and normal comparison subjects (p = 0.021) on motor coordination. The siblings performed better on sensory integration than the patients (p = 0.020) and normal comparison subjects (p = 0.036). Conclusions This study suggests that neurological soft signs might be a potential biomarker for schizophrenia, but might not be an endophenotype for schizophrenia.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Gottesman II / 1994 / Schizophrenia epigenesis: past, present, and future / Acta Psychiatr Scand Suppl 384:26~33
Petronis A / 2004 / The origin of schizophrenia: genetic thesis, epigenetic antithesis, and resolving synthesis / Biol Psychiatry 55:965~970
McNeil TF / 2000 / Minor physical anomalies and obstetric complications in schizophrenia / Aust N Z J Psychiatry (34Suppl):S65~S73
Hultman CM / 1997 / Prenatal and neonatal risk factors for schizophrenia / Br J Psychiatry 170:128~133
Curtis CE / 1999 / Relationship between nailfold plexus visibility and clinical, neuropsychological, and brain structural measures in schizophrenia / Biol Psychiatry 46:102~109
Petronis A / 2004 / The origin of schizophrenia: genetic thesis, epigenetic antithesis, and resolving synthesis / Biol Psychiatry 55:965~970
McNeil TF / 2000 / Minor physical anomalies and obstetric complications in schizophrenia / Aust N Z J Psychiatry (34Suppl):S65~S73
Hultman CM / 1997 / Prenatal and neonatal risk factors for schizophrenia / Br J Psychiatry 170:128~133
Curtis CE / 1999 / Relationship between nailfold plexus visibility and clinical, neuropsychological, and brain structural measures in schizophrenia / Biol Psychiatry 46:102~109
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