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논문 기본 정보

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학술저널
저자정보
Deandrade, Sergio Faloni (programa de mestrado em Ciencias Farmaceuticas, Nucleo de Investigacoes Quimico-Farmaceuticas [NIQFAR], Universidade do Vale do Itajai -UNIVALI) Comunello, Eros (Programa de Mestrado em Computacao Aplicada, Universidade do Vale do Itajai - UNIVALI) Noldin, Vania Floriani (Nucleo de Ciencia e Tecnologia, Area de Ciencias Biologicas e da Saude, Universidade do Oeste de Santa Catarina) Monache, Franco Delle (Dipartimento Chimica e Tecnologia delle Sostanze Biologicamente Attive, Universita di Roma) Filho, Valdir Cechinel (programa de mestrado em Ciencias Farmaceuticas, Nucleo de Investigacoes Quimico-Farmaceuticas [NIQFAR], Universidade do Vale do Itajai -UNIVALI) Niero, Rivaldo (programa de mestrado em Ciencias Farmaceuticas, Nucleo de Investigacoes Quimico-Farmaceuticas [NIQFAR], Universidade do Vale do Itajai -UNIVALI)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제31권 제1호
발행연도
2008.1
수록면
41 - 46 (6page)

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The hexane, chloroform, ethyl acetate and aqueous-soluble fractions from leaves of Maytenus robusta (Celastraceae) were evaluated for their protective actions against ethanol-induced gastric lesions in rats. The treatment with all fractions (150 mg/kg) and omeprazol (30 mg/kg) significantly reduced the lesion index, the total lesion area, and the percentage of lesion, in comparison with the control group (p<0.05). Since the ethyl acetate-soluble fraction was found to be most active in the pylorus ligated model, this fraction was further investigated and resulted in the isolation of triterpene 3, 15-dioxo-21${\alpha}$-hydroxy friedelane. The triterpene was evaluated in the HCI/ethanol-induced ulcer model in mice. In this assay, both the groups treated with 3, 15-dioxo-21${\alpha}$-hydroxy friedelane and omeprazol, at a dose of 30 mg/kg, presented a significant redduction in lesion index, total lesion area, and in the percentage of the lesion, when compared with the control group (p<0.05). The result suggests that the antiulcer effect observed in the extract and fractions may be attributed, at least in part, to this compound. Further experiments are underway to determine which antiulcer mechanisms involved in gastroprotection.

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