지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 23 - 29 (7page)
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초록· 키워드
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Objectives: Dyslipidemia in diabetes mellitus is a significant risk factor for the development of cardiovascular complications. The aim of this study was to evaluate the effect of the ethyl-acetate fraction of an ethanolic extract from Streospermum suaveolens on lipid metabolism in streptozotocin (STZ)-induced diabetic rats.
Methods: Diabetes was induced by intraperitonial injection of STZ (50 mg/kg). Diabetic rats were treated with an ethyl-acetate fraction orally at doses of 200 and 400 mg/kg daily for 14 days. On the 15th day, serum lipid profiles, such as total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL), were estimated in experimental rats. The atherogenic (AI) and the coronary risk (CRI) indices were also evaluated.
Results: The ethyl-acetate fraction at doses of 200 and 400 mg/kg significantly (P < 0.001) and dose-dependently reduced serum cholesterol, triglycerides and LDL, but increased HDL towards near normal levels as compared to diabetic control rats. The fraction also significantly (P < 0.001) lowered the atherogenic index (AI) and coronary risk index (CAI) in a dose-dependent manner.
Conclusion: The present study demonstrated that the ethyl-acetate fraction of Stereospermum suaveolens exhibits a potent antihyperlipidemic activity in hyperglycemic rats and suggests that the plant may have therapeutic value in treating the diabetic complication of hyperlipidemia.
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참고문헌 (28)
참고문헌 신청
/ 1976 / The wealth of India: Raw materials / CSIR Publication : 49 ~ 52
Abbott RD / 1988 / High density lipoprotein cholesterol, total cholesterol screening and myocardial infarction. The Framingham Study / Arterosclerosis 8 (3) : 207 ~ 211
Alladi S / 1989 / Induction of hypercholesterolemia by supplementing soy protein with acetate-generating amino acids / Nutrition Reports International 40 (5) : 893 ~ 990
Annapurna A / 2001 / Antidiabetic activity of a polyherbal preparation (tincture of panchparna) in normal and diabetic rats / Indian J Exp Biol 39 (5) : 500 ~ 502
Balasubramanian T / 2009 / Antihyperglycemic and antioxidant activities of medicinal plant Stereospermum suaveolens in streptozotocin- induced diabetic rats / J Diet Suppl 6
Abbott RD / 1988 / High density lipoprotein cholesterol, total cholesterol screening and myocardial infarction. The Framingham Study / Arterosclerosis 8 (3) : 207 ~ 211
Alladi S / 1989 / Induction of hypercholesterolemia by supplementing soy protein with acetate-generating amino acids / Nutrition Reports International 40 (5) : 893 ~ 990
Annapurna A / 2001 / Antidiabetic activity of a polyherbal preparation (tincture of panchparna) in normal and diabetic rats / Indian J Exp Biol 39 (5) : 500 ~ 502
Balasubramanian T / 2009 / Antihyperglycemic and antioxidant activities of medicinal plant Stereospermum suaveolens in streptozotocin- induced diabetic rats / J Diet Suppl 6
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