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학술저널
저자정보
Jang, Hye-Ock (Departments of Dental Pharmacology and Biophysics) Kim, Ji-Suk (Departments of Microbiolgy Pusan National University) Kwon, Woo-Cheol (Departments of Oral and Maxillofacial Surgery and Clinical Pharmacology Pusan National University) Kim, Jeong-Kuk (Departments of Dental Pharmacology and Biophysics) Ko, Myung-Suk (Departments of Dental Pharmacology and Biophysics) Kim, Dong-Hoo (Departments of Dental Pharmacology and Biophysics) Kim, Won-Il (Departments of Dental Pharmacology and Biophysics) Jeon, Young-Chan (Departments of Prosthodontics and Pusan National University) Chung, In-Kyo (Departments of Oral and Maxillofacial Surgery and Clinical Pharmacology Pusan National University) Shin, Sang-Hun (Departments of Oral and Maxillofacial Surgery and Clinical Pharmacology Pusan National University) Chung, Jin (Departments of Microbiolgy Pusan National University) Bae, Moon-Kyung (Oral Physiology and Molecular Biology, College of Dentistry and Research Institute for Oral Biotechnology Pusan National University) Yun, Il (Departments of Dental Pharmacology and Biophysics)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제31권 제2호
발행연도
2008.1
수록면
188 - 194 (7page)

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To further understand the significance of bone as a target tissues of lead toxicity, as well as a reservoir of systemic lead, it is necessary to define the effect of lead on the calcium release activated calcium influx (CRACI) in primary cultures of human osteoblast-like cells (OLC). $Pb^{2+}$ inhibited the immediate CRACI dose-dependent manner. Influx of $Pb^{2+}$ into human OLC was increased dose-dependent manner. The present study demonstrates that the interference of $Pb^{2+}$ with CRACI of human OLC is at least twofold: (1) the initiation of CRACI, i.e., the measurable influx of $Ca^{2+}$ upon $Ca^{2+}$ readdition, is partially inhibited by $Pb^{2+}$ and (2) the influx of $Pb^{2+}$ was enhanced after CRACI had been induced.

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