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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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초록· 키워드
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Stems and roots of Acanthopanax koreanum Nakai were extracted with water and treated on immune cells in order to determine their immunomodulatory activites. Various Th-1 type cytokines were measured using ELISA including interleukin (IL)-2, IL-12, interferon-gamma (IFN-$gamma$), and tumor necrosis factor-alpha (TNF-$\alpha$) secreted by dendritic cells, T-cells, intestinal epithelial cells, natural killer cells, and macrophages. As a result, there was a significant increase in IL-12 and IFN-$\gamma$, secretion, but there was no change in the secretion of TNF-$alpha$. Additionally T-cells slightly increased the secretion of IL-2, but there was a significant increase of IL-2 in intestinal epithelial cells. Therefore, our results suggest that A. koreanum Nakai may act as an immunomodulator by stimulating the cell-mediated immunity which can help the immune system defend against infections or cancer cells.
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참고문헌 (33)
참고문헌 신청
Yook, C. S / 1978 / A new form of Acanthopanax species (I) / Kor. J. Pharmacogn 7:179
Lee, Y. S / 2001 / Some pharmacological activities of acanthoic acid isolated from Acanthopanax koreanum root bark / J. Appl. Pharmacol 9:176
Kim, Y. H / 1985 / Studies on the chemical constituents of Acanthopanax koreanum / Kor. J.Pharmacogn 16:151
Kim, Y. H / 1988 / Studies on the constituents of Acanthopanax koreanum / Arch. Pharm. Res 11:159
JongSeongKang / 2003 / Determination of Chiisanoside in Acanthopanax Species by High Performance Liquid Chromatography / Natural Product Sciences 9(2):45~48
Lee, Y. S / 2001 / Some pharmacological activities of acanthoic acid isolated from Acanthopanax koreanum root bark / J. Appl. Pharmacol 9:176
Kim, Y. H / 1985 / Studies on the chemical constituents of Acanthopanax koreanum / Kor. J.Pharmacogn 16:151
Kim, Y. H / 1988 / Studies on the constituents of Acanthopanax koreanum / Arch. Pharm. Res 11:159
JongSeongKang / 2003 / Determination of Chiisanoside in Acanthopanax Species by High Performance Liquid Chromatography / Natural Product Sciences 9(2):45~48
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