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자료유형
학술저널
저자정보
Lee, Bo-Mi (Department of Life and Nanopharmaceutical Sciences and Department of Pharmaceutical Science, Kyung Hee University) Shin, Yong-Wook (Department of Life and Nanopharmaceutical Sciences and Department of Pharmaceutical Science, Kyung Hee University) Bae, Eun-Ah (Department of Life and Nanopharmaceutical Sciences and Department of Pharmaceutical Science, Kyung Hee University) Han, San-Jun (Department of Life and Nanopharmaceutical Sciences and Department of Pharmaceutical Science, Kyung Hee University) Kim, Joo-Sun (Institute of Natural Products, Seoul National University) Kang, Sam-Sik (Institute of Natural Products, Seoul National University) Kim, Dong-Hyun (Department of Life and Nanopharmaceutical Sciences and Department of Pharmaceutical Science, Kyung Hee University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제31권 제4호
발행연도
2008.1
수록면
445 - 450 (6page)

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The root of Paeonia lactiflora PALL (PL, Family Paeoniaceae) has been used frequently as an antipyretic and anti-inflammatory agent in traditional medicines of Korea, China and Japan. To evaluate antiallergic effect of PL, we isolated its main constituents, paeoniflorin and paeonol, and evaluated in vivo their inhibitory effects against passive cutaenous anaphylaxis (PCA) reaction induced by IgE-antigen complex and scratching behaviors induced by compound 48/80. PL, paeoniflorin and paeonol potently inhibited PCA reaction and scratching behaviors in mice. Paeoniflorin exhibited the most potent inhibition against scratching behaviors and the acetic acid-induced writhing syndrome in mice. Paeonol most potently inhibited PCA reaction and mast cells degranulation. These findings suggest that PL can improve IgE-induced anaphylaxis and scratching behaviors, and may be due to the effect of its constituents, paeoniflorin and paeonol.

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