지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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N-Phenylthiourea derivatives and catechol oxidase receptor complex was studied using molecular mechanics method. The starting structure was adopted from the protein databank and the calculation of energy minimization and molecular dynamics was performed with AMBER package. The molecular dynamics showed that the simulation time span of 20 ns was long enough to observe the interaction profile and stationary ligand-receptor configuration in the complex. The conformation of the ligand was related to the interaction to the receptor and the efficacy was also interpreted in this context.
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참고문헌 (19)
참고문헌 신청
Karlin, K. D / 1993 / Metalloenzymes, structural motifs, and inorganic models / Science 261:701
Kim, Y. J / 2005 / Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future / Cell. Mol. Life Sci 62:1707
Ando, H / 2007 / Approaches to identify inhibitors of melanin biosynthesis via the quality control of tyrosinase / J. Inves. Dermatol 127:751
Klabunde, T / 1998 / Crystal structure of a plant catechol oxidase containing a dicopper center / Nat. Struct. Biol 5:1084
Thanigaimalai, P / 2010 / Design and synthesis of novel hydroxyalkylaminomethylchromones for their IL-5 inhibitory activity / Bioorg. Med. Chem 18:4625
Kim, Y. J / 2005 / Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future / Cell. Mol. Life Sci 62:1707
Ando, H / 2007 / Approaches to identify inhibitors of melanin biosynthesis via the quality control of tyrosinase / J. Inves. Dermatol 127:751
Klabunde, T / 1998 / Crystal structure of a plant catechol oxidase containing a dicopper center / Nat. Struct. Biol 5:1084
Thanigaimalai, P / 2010 / Design and synthesis of novel hydroxyalkylaminomethylchromones for their IL-5 inhibitory activity / Bioorg. Med. Chem 18:4625
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