지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
The aim of the present study was to optimize in vitro method for the prediction of drug-induced liver injury using human liver microsomes (HLM). Cytotoxicity test of cyclophosphamide and acetaminophen in HepG2 cells cultured with HLM showed that the newly established condition using 0.375 mg/ml HLM for 24 hr incubation was comparable or more sensitive than the previously established condition using 0.75 mg/ml HLM for 12 hr incubation. Although the cytotoxic effect of troglitazone was completely attenuated by 0.75 mg/ml HLM, it was augmented by 0.375 mg/ml HLM in the presence of the NADPH-generating system. The cytotoxic effect of chlormezanone, a withdrawn drug due to hepatotoxicity in human, was increased by HLM in the presence of the NADPH-generating system. In contrast, the cytotoxic effect of methapyrilene, a withdrawn drug due to hepatotoxicity in rats, was decreased by HLM in the presence of the NADPH-generating system. The present study suggests that the optimized in vitro method using HLM can be useful for the prediction of drug-induced hepatotoxicity.
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Kaplowitz, N / 2005 / Idiosyncratic drug hepatotoxicity / Nat. Rev. Drug Discov 4:489
Guengerich, F. P / 2007 / Applying mechanisms of chemical toxicity to predict drug safety / Chem. Res. Toxicol 20:344
Park, B. K / 2005 / The role of metabolic activation in druginduced hepatotoxicity / Annu. Rev. Pharmacol. Toxicol 45:177
Donato, M. T / 2008 / Cell lines: a tool for in vitro drug metabolism studies / Curr. Drug Metab 9:1
Guillouzo, A / 1998 / Liver cell models in in vitro toxicology / Environ. Health Perspect 106(Suppl. 2):511
Guengerich, F. P / 2007 / Applying mechanisms of chemical toxicity to predict drug safety / Chem. Res. Toxicol 20:344
Park, B. K / 2005 / The role of metabolic activation in druginduced hepatotoxicity / Annu. Rev. Pharmacol. Toxicol 45:177
Donato, M. T / 2008 / Cell lines: a tool for in vitro drug metabolism studies / Curr. Drug Metab 9:1
Guillouzo, A / 1998 / Liver cell models in in vitro toxicology / Environ. Health Perspect 106(Suppl. 2):511
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
In-vitro and in-vivo pharmacokinetics of IS01957, p-coumaric acid derivative using a validated LC?ESI?MS/MS method in mice plasma
Journal of Pharmaceutical Investigation
2018 .09
-
Comparison of in vitro models for drug-induced liver injury assessment
Journal of Biomedical and Translational Research
2024 .06
-
Genetic variation and relationship of three dimensional structure like human liver, evaluation method of hepatotoxicity and conjugate like human liver
Annals of Hepato-Biliary-Pancreatic Surgery
2022 .12
-
Inhibition of Cytochrome P450 by Propolis in Human Liver Microsomes
Toxicological Research
2016 .07
-
How useful are liver function tests in vitro in human hepatoma cell line (HepG2)?
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Evaluation of Adverse Drug Properties with Cryopreserved Human Hepatocytes and the Integrated Discrete Multiple Organ Co-culture (IdMOCTM) System
Toxicological Research
2015 .06
-
Factors Influencing Imatinib-Induced Hepatotoxicity
Cancer Research and Treatment
2020 .01
-
Liver
대한외과학회 학술대회 초록집
2016 .11
-
Adverse outcome pathways associated with drug-induced liver injury
환경독성보건학회 심포지엄 및 학술대회
2017 .10
-
티로신 키나아제 저해제의 간독성에 대한 고찰
한국임상약학회지
2019 .01
-
Successful salvage treatment of acute graft-versus-host disease after liver transplantation by withdrawal of immunosuppression : a case report
Annals of Hepato-Biliary-Pancreatic Surgery
2016 .02
-
Comparison of liver injury markers in 2D and 3D cell culture models: AST, ALT and LDH assays after hepatotoxicants treatment
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Portulaca oleracea Seed Oil Exerts Cytotoxic Effects on Human Liver Cancer (HepG2) and Human Lung Cancer (A-549) Cell Lines
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Preclinical Assessment of the Anticancer Drug Response of Plexiform Neurofbroma Tissue Using Primary Cultures
Journal of Clinical Neurology
2015 .01
-
Drug-Induced Liver Injury: Pattern Recognition and Future Directions
Gut and Liver
2016 .01
-
약인성 간손상 환자에 대한 生肝湯 치험 1례
대한한방내과학회지
2019 .01
-
한방치료 중 약인성 간손상으로 추정되는 환자에 대한 치료레이저 치험 1례
한방재활의학과학회지
2016 .01
-
Determination of pre-dose genetic biomarkers associated with susceptibility to drug-induced hepatotoxicity
환경독성보건학회 심포지엄 및 학술대회
2019 .04
-
Correlation between Drug Market Withdrawals and Socioeconomic, Health, and Welfare Indicators Worldwide
Journal of Korean Medical Science
2015 .01
-
한방병원에 입원한 환자 147명의 간기능 검사에 대한 후향적 관찰
동의생리병리학회지
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0