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Effect of Defatted Torreya nucifera Seed Extract on the Cross-linking of Advanced Glycation End Products to Collagen
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논문 기본 정보

Type
Academic journal
Author
Son, Dahee (바이오스펙트럼[주] 생명과학연구소) Kim, Minkyung (바이오스펙트럼[주] 생명과학연구소) Park, Deokhoon (바이오스펙트럼[주] 생명과학연구소) Jung, Eunsun (바이오스펙트럼[주] 생명과학연구소)
Journal
대한화장품학회 대한화장품학회지 대한화장품학회지 제45권 제1호
Published
2019.1
Pages
19 - 25 (7page)

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Effect of Defatted Torreya nucifera Seed Extract on the Cross-linking of Advanced Glycation End Products to Collagen
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Advanced glycation end products (AGEs) are final products formed by glycation reaction between reducing sugars and proteins, lipids or nucleic acids. These AGEs are related to progress of skin aging. In this study, we evaluate anti-aging activity of Defatted Torreya nucifera seed extract (DTSE) through antioxidant, anti-glycation, anti-elastase and inhibitory and breaking activity on the cross-linking of AGEs to collagen assay. Results showed that DTSE contained polyphenols and flavonoids. The $IC_{50}$ values of 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activity were $16.4{\mu}g$ (Dried materials, DM)/mL and $16.7{\mu}g\;DM/mL$, respectively. DTSE also inhibited the formation of AGEs, elastase activity and cross-linking of AGEs to collagen as well as broke existing cross-linking of AGEs to collagen in a dose-dependent manner. Consequently, our findings suggest that DTSE could be useful as a cosmetic material with anti-aging activity.
#Torreya nucifera #AGEs #anti-aging #antioxidant #anti-glycation

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