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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 187 - 202 (16page)
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초록· 키워드
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Objectives : Non-invasive transcranial electrical stimulation is one of therapeutic interventions to change in neural excitability of the cortex. Transcranial electro-acupuncture (TEA) can modulate brain functions through changes in cortical excitability as a model of non-invasive transcranial electrical stimulation. Some composites of fermented Scutellaria baicalenis (FSB) can activate intercellular signaling pathways for activation of brain-derived neurotrophic factor that is critical for formation of neural plasticity in stroke patients. This study was aimed at evaluation of combinatory treatment of TEA and FSB on behavior recovery and cortical neural excitability in rodent focal stroke model. Methods : Focal ischemic stroke was induced by photothrombotic injury to the motor cortex of adult rats. Application of TEA with 20 Hz and $200{\mu}A$ in combination with daily oral treatment of FBS was given to stroke animals for 3 weeks. Motor recovery was evaluated by rotating bean test and ladder working test. Electrical activity of cortical pyramidal neurons of stroke model was evaluated by using multi-channel extracellular recording technique and thallium autometallography. Results : Compared with control stroke group who did not receive any treatment, Combination of TEA and FSB treatment resulted in more rapid recovery of forelimb movement following focal stroke. This combination treatment also elicited increase in spontaneous firing rate of putative pyramidal neurons. Furthermore expression of metabolic marker for neural excitability was upregulated in peri-infract area under thallium autometallography. Conclusions : These results suggest that combination treatment of TEA and FSB can be a possible remedy for motor recovery in focal stroke.
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등록된 정보가 없습니다.
참고문헌 (39)
참고문헌 신청
Wang Xiaoming / 2016 / Atlas of clinical anatomy and scalp acupuncture lines / Koonja :1~164
Ha Chi-Hong / 2001 / A clinical study on 29 cases with stroke treated by common acupuncture therapy and scalp acupuncture / The Journal of Korean Acupuncture and Moxibustion Society 18(3):82~90
T Schockert / 2018 / Cortical Activation by Yamamoto New Scalp Acupuncture in the Treatment of Patients with a Stroke: A Sham-Controlled Study Using Functional Mri / Acupuncture in Medicine 28(4):212~214
Wen-wen Wang / 2015 / A systematic review and meta-analysis of Baihui (GV20)-based scalp acupuncture in experimental ischemic stroke / Scientific Reports 4(1):3981
Zhang ZJ / 2012 / Neural acupuncture unit: a new concept for interpreting effects and mechanisms of acupuncture / Evid Based Complement Alternat Med :1~23
Ha Chi-Hong / 2001 / A clinical study on 29 cases with stroke treated by common acupuncture therapy and scalp acupuncture / The Journal of Korean Acupuncture and Moxibustion Society 18(3):82~90
T Schockert / 2018 / Cortical Activation by Yamamoto New Scalp Acupuncture in the Treatment of Patients with a Stroke: A Sham-Controlled Study Using Functional Mri / Acupuncture in Medicine 28(4):212~214
Wen-wen Wang / 2015 / A systematic review and meta-analysis of Baihui (GV20)-based scalp acupuncture in experimental ischemic stroke / Scientific Reports 4(1):3981
Zhang ZJ / 2012 / Neural acupuncture unit: a new concept for interpreting effects and mechanisms of acupuncture / Evid Based Complement Alternat Med :1~23
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