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고영광; 김원일; 김철주; 권오경; 황진상; 권오형

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자료유형: 학술저널

저자정보: 고영광 (금오공과대학교 고분자공학과) 김원일 (금오공과대학교 고분자공학과) 김철주 (금오공과대학교 고분자공학과) 권오경 (경북대학교병원 일반외과) 황진상 ([주]이그잭스) 권오형 (금오공과대학교 고분자공학과)

저널정보: 한국섬유공학회 한국섬유공학회지 한국섬유공학회지 제47권 제2호

발행연도: 2010.1

수록면: 153 - 162 (10page)

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One of the serious complications that have not been solved yet in modern medicine is a postoperative tissue adhesion of internal organs. Tissue adhesions are associated with numerous postoperative complications, including pain, functional obstruction and difficult re-operative surgery. In this study, poly($\gamma$-glutamic acid)($\gamma$-PGA) based nanofiber sheets were prepared by using electrospinning technique to evaluate the ability of the prevention of postoperative tissue adhesion. The anti-adhesion membranes were prepared from $\gamma$-PGA and poly(D,L-lactic-co-glycolic acid)(PLGA) with different compositions by electrospinning. Also non-steroidal anti-inflammatory drug (ibuprofen) was incorporated during fabrication of nanofibers. Various electrospun nanofibers were characterized by SEM, FTIR, water contact angle measurement, biodegradability test, in vitro drug release profile, cell culture test, and in vivo animal study using Sprague Dawley rat model. The average diameter of the nanofibers electrospun from the various biodegradable polymer solutions ranged from 300 nm to 900 nm, approximately. From in vivo animal study, it was observed that ibuprofen-incorporated $\gamma$-PGA nanofiber sheet (crosslinked) was significantly effective in preventing post-surgical tissue adhesion and wound healing, probably due to the appropriate hydrophilicity preventing shrinkage of the sheet. On the other hand, PLGA nanofibrous mat was dramatically contracted in vivo due to its high hydrophobicity and resulted in insufficient coverage of wound.

#poly #$gamma$-glutamic acid) #nanofiber #electrospinning #PLGA tissue adhesion-barrier

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