지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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In the field of surgery, several instances of adhesions in the abdomen, bowel, uterus, and pelvis are observed. Severe post-operative adhesions cause pain in the pelvis and bowel, infertility, and intestinal obstruction. Despite much interest in preventing postoperative adhesion, these symptoms appear persistently. In this study, various composition of chitosan and PLGA blend nanofibrous sheets containing a small quantity of nonionic surfactant, polysorbate80 were fabricated by electrospining technique for application to anti-adhesion barrier. The average diameter of fabricated nanofibers as determined by SEM ranged between 100 to 130 nm. Surface hydrophilicity and biodegradability of nanofibrous mats increased with increasing chitosan content. However, cell attachment and proliferation on nanofibrous surfaces were decreased with increasing chitosan content, probably due to enhanced hydrophilicity. In vivo animal test confirmed that the Chitosan/PLGA(5:5)/Polysorbate80 nanofibrous sheet was sufficiently effective, than the PLGA nanofibrous sheet, in preventing undesired tissue adhesion.
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참고문헌 (26)
참고문헌 신청
H. Ellis / 1971 / The Cause and Prevention of Postoperative Intraperitoneal Adhesion / Surg. Gynecol. Obstet 133:497~511
N. F. Ray. / 1998 / Abdominal Adhesiolysis : Inpatient Care and Expenditures in the United States in 1994 / J. Am. Coll. Surg 186:1~9
Cary B. Linsky / 1991 / Method and Material for Prevention of Surgical Adhesions / US Patent, 5,002,551 :002
오애경 / 2013 / 유착 방지제의 현황 / 생체재료학회지 17(4):138~145
송형준 / 2009 / 복벽 손상 백서에서 세가지 유형의 유착방지제의 효과 / 대한외과학회지 77(1):7~14
N. F. Ray. / 1998 / Abdominal Adhesiolysis : Inpatient Care and Expenditures in the United States in 1994 / J. Am. Coll. Surg 186:1~9
Cary B. Linsky / 1991 / Method and Material for Prevention of Surgical Adhesions / US Patent, 5,002,551 :002
오애경 / 2013 / 유착 방지제의 현황 / 생체재료학회지 17(4):138~145
송형준 / 2009 / 복벽 손상 백서에서 세가지 유형의 유착방지제의 효과 / 대한외과학회지 77(1):7~14
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