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자료유형
학술저널
저자정보
Gilani, Anwar H. (Department of Pharmacology, The Aga Khan University Medical College, Faculty of Health Sciences) Janbaz, K.H. (Department of Pharmacology, The Aga Khan University Medical College, Faculty of Health Sciences) Zaman, M. (Department of Pharmacology, The Aga Khan University Medical College, Faculty of Health Sciences) Lateef, A. (Department of Pharmacology, The Aga Khan University Medical College, Faculty of Health Sciences) Tariq, S.R. (Physiology, The Aga Khan University Medical College, Faculty of Health Sciences) Ahmad, H.R. (Physiology, The Aga Khan University Medical College, Faculty of Health Sciences)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제17권 제3호
발행연도
1994.1
수록면
145 - 149 (5page)

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Intravenous administration of hydro-methanolic extract of Cyperus scariosus (3-10 mg/kg) produced hypotensive and bradcardiac effects. These effects remianed unaltered in atropinized animals indicating that cardiovascular effects of the plant extract are not medliated through activation of muscarinic receptors. In the in vitro studies, it suppressed the spontaneous contractions of guinea-pig paired atria, rat ulterus and rabbit jejunum in a concentration-dependent (0.1-1 mg/ml) manner. It also inhibited histanmine or acetylcholine-induced contractions of guinea-pig ieum indicating non-sepcific spasmolytic action. In rabbit aorta, it inhibited norepinephrine $(10\;mu{M)}$ as well as $K^+$ (80mM)-induced contractions at similar concentrations (0.1-1 mg/ml). These data indicate that cyperus scariosus contains $Ca^{2+}$ channel blocker-like constituent(s) which may explain hypotensive effect observed in vivo and the general spasmolytic activity of plant explain its folkloric use in diarrhoea.

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