Effects of Brazilin on Induction of Immunological Tolerance by Sheep Red Blood Cells in C57BL/6 Female Mice

Mok, Myoung-Soo; Jeon, Sun-Duck; Yang, Kyoung-Mee; So, Dhong-Su; Moon, Chang-Kiu

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자료유형: 학술저널

저자정보: Mok, Myoung-Soo (College of Pharmacy, Seoul National University) Jeon, Sun-Duck (College of Pharmacy, Seoul National University) Yang, Kyoung-Mee (College of Pharmacy, Seoul National University) So, Dhong-Su (College of Pharmacy, Seoul National University) Moon, Chang-Kiu (College of Pharmacy, Seoul National University)

저널정보: 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제21권 제6호

발행연도: 1998.1

수록면: 769 - 773 (5page)

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Brazilin was examined for its effects on the induction of immunological tolerance. Brazilin was administered to C57BL/6 female mice for 2 consecutive days before the immunization with high dose SRBC (109 cells) which can produce immunological tolerance. Delayed type hypersensitivity, IgM plaque forming cells, ConA induced IL-2 production and mitogen- or antigen-induced proliferation of lymphocytes were measured as evaluation parameters. Administration of brazilin prior to immunization could keep the DTH and IL-2 production almost optimaly immunized levels. Brazilin also inhibited the elevation of non-specific suppressor cell activity. ConA induced proliferation of splenocytes in high dose SRBC immunized mice was significantly decreased by pretreatment of brazilin. And this might be one of the reason for augmentation of DTH by brazilin. However, IgM plaque forming cells were not affected by the treatment of brazilin. These results indicate that brazilin prevents the induction of mmunological tolerance caused by high dose SRBC by suppressing the elevation of suppressor cell activity and by inhibiting the decrease in IL-2 production in C57BL/6 female mice.

#Brazilin #Eaesalpinia sappan #Immunological tolerance #Delayed type hypersensitivity #Interleukin-2 #Nonspecific suppressor activity

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