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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology 제12권 제4호
- 발행연도
- 2004.1
- 수록면
- 228 - 234 (7page)
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Brazilin shows hypoglycemic effect in diabetic animals through enhancement of glucose metabolisms in insulin responsive tissues. One of the major mechanisms of brazilin to enhance glucose metabolism is stimulation of glucose transport in adipocytes. In this study, the essential molecular moiety of brazilin for the stimulation of glucose transport was investigated. We found that brazilin undergoes a structural change in physiological buffer and produces hydrogen peroxide. Methylation of hydroxyl group of brazilin or addition of catalase along with brazilin resulted in the complete inhibition of brazilin-induced glucose transport in adipocytes. Because hydrogen peroxide increases glucose transport by inhibition of phosphatases, we examined the effect of brazilin on phosphatase activity. Brazilin inhibited phosphatases in a wide range of activity, and protein phosphatase 1 and 2A were also inhibited. These results suggest that the production of hydrogen peroxide by oxidation of catechol hydroxyl group of brazilin mediates glucose transport through inhibition of phosphatases which otherwise decrease glucose transport in adipocytes.
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Effect of brazilin on phosphatase activity in isolated rat epididymal adipocytes
한국응용약물학회 춘계학술발표논문집
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Effects of Brazilin on Glucose Metabolism in Epididymal Adipocytes from Streptozotocin induced Diabetic Rats
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Binding of brazilin to cellular proteins in isolated rat epididymal adipocytes
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A Study on Membrane Transport of Brazilin Using Primary Cultured Rat Hepatocytes
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1991 .12
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Effects of Brazilin Glucose Metabolism in Isolated Soleus Muscles from Streptozotocin Induced Diabetic Rats
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Diabetes, Glucose Transport and Hypoglycaemic Agents
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Alloxan 유도 당뇨병상태에서 과산화지질생성에 미치는 Brazilin의 효과 ( Antilipidperoxidative Effects of Brazilin in Alloxan - induced Diabetic Mice )
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Immunomodulating Activities of Brazilin and Hematoxylin in Normal Young Mice
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Brazilin Modulates the Immune Functions in Normal CBA Female Mice
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A Study on the Inhibition of 2-deoxy-D-Glucose Transport of the Endogenous Glucose Transporters in Spodoptera frugiperda Clone 21-AE Cells by Using Hexoses
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