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논문 기본 정보

자료유형
학술저널
저자정보
Yoon, Do-Young (Genetic Engineering Center, Korea Institute of Science and Technology) Kim, Jae-Wha (Genetic Engineering Center, Korea Institute of Science and Technology) Hwang, Soo-Weon (Genetic Engineering Center, Korea Institute of Science and Technology) Choi, Myung-Ja (Genetic Engineering Center, Korea Institute of Science and Technology) Choe, In-Seong (Genetic Engineering Center, Korea Institute of Science and Technology) Kim, Jong-Bae (Animal Husbandry College, Konkuk University) Chung, Tae-Wha (Genetic Engineering Center, Korea Institute of Science and Technology)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제12권 제4호
발행연도
1989.1
수록면
269 - 275 (7page)

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Early embryo development and implantation were arrested in ICR mice which were passively immunized with a mouse monoclonal progesterone amtibody given as a single intraperitoneal injection at 12 hrs or 60 hrs post coitum (p. c.). Unimplanted embryos were recovered from the reproductive tract of the antibody-treated mice and none of these progressed to the blastocyst stage. The most pronounced effect was an arrest of embryonic development at a stage prior to cavitation. The plasma progesterone concentration in the blood taken by carbiac puncture increased greatly after the treatment by virtue of high affinity binding by the antibody in circulation. The result showed that passive immunization against progesterone shortly after mating interfered with early hormone dependent steps which were essential for normal embryonic development.

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