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자료유형
학술저널
저자정보
Hong, Seung-Heon (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) Oh, Myung-Jin (College of Oriental Medicine, Wonkwang University) Lee, Eon-Jeong (College of Oriental Medicine, Wonkwang University) Park, Jin-Han (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) Kim, Na-Hyung (Department of Pharmacy, College of Pharmacy, Wonkwang University) Rhee, Hyung-Koo (Division of Respiratory System, Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University) Kim, Hyung-Min (Department of Pharmacology, College of Oriental Medicine, Kyung Hee University) Jung, Sung-Ki (Division of Respiratory System, Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University)
저널정보
경희한의학연구센터 Oriental pharmacy and experimental medicine Oriental pharmacy and experimental medicine 제4권 제1호
발행연도
2004.1
수록면
60 - 64 (5page)

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The effect of aqueous extract of processed Xanthii fructus (PXF) on cell viability and histamine release from mast cell has been investigated. PXF showed higher cell viability than unprocessed Xanthii fructus (XF) at the concentrations of 5 and 10 mg/ml. Aqueous extract of PXF and unprocessed XF inhibited compound 48/80-induced systemic anaphylaxis in mouse. Both PXF and unprocessed XF dose-dependently inhibited histamine release from rat peritoneal mast cells by compound 48/80 to the similar extent at 0.01, 0.1 and 1 mg/ml. Our studies provide evidence that processing of XF may be beneficial to reduce cytotoxicity in high concentration (at 5 and 10 mg/ml) but does not affect on anti-allergic activity.

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