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논문 기본 정보

자료유형
학술저널
저자정보
An Joung-Jo (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) NamGung Uk (Department of Neurophysiology, College of Oriental Medicine, Daejeon University) Seo In-Chan (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) Kim Yoon-Sik (Department of Internal Medicine, College of Oriental Medicine, Daejeon University)
저널정보
대한동의생리학회 동의생리병리학회지 동의생리병리학회지 제19권 제6호
발행연도
2005.1
수록면
1,640 - 1,646 (7page)

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An oriental medicinal drugs Jahageo (JHG, Hominis placenta) were examined to determine its effects on the responsiveness of central nervous system neurons after injury. We found that JHG was involved in neurite outgrowth of DRG sensory axons. JHG treatment also increased expression of axonal growth-associated protein GAP-43 in DRG sensory neurons after sciatic nerve injury and in the injured spinal cord. JHG treatment during the spinal cord injury increased induction levels of cell division cycle 2 (Cdc2) protein in DRG as well as in the spinal cord. Histochemical investigation showed that induced Cdc2 in the injured spinal cord was found in non-neuronal cells. These results suggest that JHG regulates activities of non-neuronal cells such as oligodendrocyte and astrocyte in responses to spinal cord injury and protects neuronal responsiveness after axonal damage.

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