지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.6
- 수록면
- 107 - 111 (5page)
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초록· 키워드
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Estrogen exerts a neuroprotective effect by reducing apoptotic cell death in both brain injury and spinal cord injury. This study investigated whether estrogen contributes to the cleavage of poly (ADP-ribose) polymerase (PARP), an indicator of apoptotic cell death, during spinal cord injury. Adult female rats were ovariectomized and treated with oil or estrogen prior to spinal cord injury. Spinal cord tissues were collected at 24 hr after injury. Estrogen treatment showed a significant improvement of spinal cord tissue morphology and markedly reduced numbers of terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL)-positive cells. Using Western blot analysis, we found that the level of cleaved PARP was increased in oil-treated animals, whereas estrogen prevented the injury-induced increase in PARP cleavage. The results of this study provide further evidence that estrogen inhibits apoptotic cell death through the down-regulation of cleaved PARP in spinal cord injury.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
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UCI(KEPA) : I410-ECN-0101-2009-510-018537666