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논문 기본 정보

자료유형
학술저널
저자정보
Shim, Jin-Young (Natural Products, Research Institute, Seoul National University) Lee, Yeon-Sil (Natural Products, Research Institute, Seoul National University) Jung, Sang-Hoon (Natural Products, Research Institute, Seoul National University) Choi, Hyung-Seok (Natural Products, Research Institute, Seoul National University) Shin, Kuk-Hyun (Natural Products, Research Institute, Seoul National University) Kim, Yeong-Shik (Natural Products, Research Institute, Seoul National University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제25권 제6호
발행연도
2002.1
수록면
889 - 894 (6page)

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Acharan sulfate (AS) is a glycosaminoglycan (GAG) prepared from the giant African snail, Achatina fulica. In this study, some biological activities of AS were evaluated on the basis of structural similarities to heparin/heparan sulfate and the biological functions of GAGs. We demonstrated that it exhibited strong immunostimulating activities as measured by carbon clearance test in mice and in vivo phagocytosis. It also exhibited a significant hypoglycemic activity in epinephrine (EP)-induced hyperglycemia as well as antifatigue effects by weight-loaded forced swimming test. And it showed hypolipidemic activities in cholesterol-rich mixture induced hyperlipidemia in rats. The above results indicate that AS has diverse biological activities and suggest therapeutically important target molecules.

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