지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제25권 제1호
- 발행연도
- 2002.1
- 수록면
- 86 - 92 (7page)
이용수
초록· 키워드
오류제보하기
The enhancement of paracellular transport of heparin disaccharide using several absorption enhancers across Caco-2 cell monolayers was tested . The cytotoxicity of these enhancers was also examined. The enhancing effects by Quillaja saponin, diponin glycyrrhizinate, $18{\beta}-glycyrrhetinic$ acid, sodium caprate and taurine were determined by changes in transepithelial electrical resistance (TEER) and the amount of heparin disaccharide transported across Caco-2 cell monolayers. Among the absorption enhancers, $18{\beta}-glycyrrhetinic$ acid arid taurine decreased TEER and increased the permeability of heparin disaccharide in a dose-dependent and time-dependent manner with little or negligible cytotoxicity. Our results indicate that these absorption enhancers can widen the tight junction, which is a dominant paracellular absorption route of hydrophilic compounds . It is highly possible that these absorption enhancers can be applied as pharmaceutical excipients to improve the transport of macromolecules and hydrophilic drugs having difficulty in permeability across the intestinal epithelium.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The Intestinal Absorption of Heparin Disaccharide Using Several Absorption Enhancers in Caco-2 Monolayers
대한약학회 학술대회
2000 .01
-
Absorption Enhancement of Heparin Disaccharide through Intracellular Regulation of Paracellular Permeability by Phytolaccosides from Phytolacca americana
대한약학회 학술대회
2001 .01
-
Modulation of Tight Junctions does Not Predict Oral Absorption of Hydrophilic Compounds: Use of Caco-2 and Calu-3 Cells
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2007 .01
-
Enhancement of Heparin and Heparin Disaccharide Absorption by the Phytolacca americana Saponins
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2003 .01
-
Effects of Aralia elata Extract as an Absorption Enhancer on the Transport of Chondroitin Sulfate and Its Digestion Products in Caco-2 Cell Monolayers
대한약학회 학술대회
2001 .01
-
Transport mechanism of berberine across Caco-2 cell monolayers
대한약학회 학술대회
2001 .01
-
Effects of BuOH Extract of the Root of Aralia elata as an Absorption Enhancer on the Transport of Chondroitin Sulfate and Its Digestion Products In Vitro and In Vivo
대한약학회 학술대회
2002 .01
-
Does Agitation Condition Affect the Correlation Between in vitro Permeability of Xenobiotics across Caco-2 Cells and in vivo Bioavailability of the Compounds\ulcorner
대한약학회 학술대회
2002 .01
-
Adsorption of cyclosporin A during permeability study using Caco-2 cell monolayers
대한약학회 학술대회
2001 .01
-
Heparin, Low Molecular Weight Heparins and Analogs as Pharmaceutical Agents
대한약학회 학술대회
2005 .01
-
Prediction method on the effect of transdermal enhancer I: Flux study using model drug and enhancer
대한약학회 학술대회
2001 .01
-
Heparin 투여에 의한 혈소판 감소증에 기인하는 것으로 생각되는 색전증과 쇽
대한뇌졸중학회지
1999 .01
-
The transport of a reversible proton pump antagonist, YH18885, across Caco-2 cell monolayers
대한약학회 학술대회
2000 .01
-
Structure-transport relationship of drugs in Caco-2 monolayer system: through sildenafil derivatives and dopamine receptor antagonists
대한약학회 학술대회
2002 .01
-
혈액투석 중에 발생한 헤파린에 의한 전신 두드러기 1예
천식 및 알레르기
2009 .01
-
폴리에틸렌 옥사이드-실리콘 Segment Device 에서 헤파린 용출
약학회지
1986 .01
-
Does Low-Dose Heparin Have a Significant Role in Free Flap Surgery?
Archives of craniofacial surgery : ACFS
2017 .01
-
한국인 담석에 미치는 heparin 용액의 관류효과
Annals of Surgical Treatment and Research
1980 .06
-
Investigation of transport of PEGylated salmon calcitonin through caco-2 cell monolayers
대한약학회 학술대회
2003 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0