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논문 기본 정보

자료유형
학술저널
저자정보
Park Seung-Taeck (School of Medicine, Wonkwang University) Lee Young-Mi (School of Medicine, Wonkwang University) Hong Gi-Youn (School of Medicine, Wonkwang University) Choi Ki-Uk (School of Medicine, Wonkwang University) Min Bu-Ki (School of Medicine, Wonkwang University) Yoon Hyang-Suk (School of Medicine, Wonkwang University) Chang Chul-Ho (School of Medicine, Wonkwang University) Lee Kang-Chang (School of Medicine, Wonkwang University) Juhng Seon-Kwan (School of Medicine, Wonkwang University) Han Du-Seok (School of Dentistry, Wonkwang University) Lee Gap-Sang (College of Life Science, Wonkwang University) Seong Kang-Kyung (College of Oriental Medicine, Wonkwang University) Lee Geon-Mok (College of Oriental Medicine, Wonkwang University)
저널정보
경희한의학연구센터 Oriental pharmacy and experimental medicine Oriental pharmacy and experimental medicine 제2권 제1호
발행연도
2002.1
수록면
36 - 40 (5page)

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Effects of hydrogen peroxide $(H_2O_2)-induced$ neurotoxicity were investigated in cultured newborn rat spinal dorsal root ganglion (DRG) neurons after DRG neurons were treated in the media containning various concentrations of $H_2O_2$. In addition, the protective effect of Herba Epimedii (HE) extract against $H_2O_2-induced$ neurotoxicity was examined. Cytotoxic values were determined by the cell viability of living cells using 3-(4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide (MTT) assay. In the present study, exposure of neurons to $H_2O_2$ resulted in a significant cell death in a dose- and time-dependent manners in cultured DRG neurons. The decrement of cell viability by $H_2O_2$ was blocked by HE. These results suggest that the neuroprotective effect of HE against $H_2O_2-induced$ cytotoxicity may result from the prevention of injury induced by $H_2O_2$.

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