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논문 기본 정보

자료유형
학술저널
저자정보
Park, Seung-Taeck (School of Medicine, Wonkwang University) Kim, Jeong-Joong (School of Medicine, Wonkwang University) Jeong, Se-Jin (School of Medicine, Wonkwang University) Cho, Chung-Gu (School of Medicine, Wonkwang University) Lee, Kang-Chang (School of Medicine, Wonkwang University) Jang, Chul-Ho (School of Medicine, Wonkwang University) Park, Jae-Hwang (School of Medicine, Wonkwang University) Hong, Gi-Youn (School of Medicine, Wonkwang University) Yoon, Hyang-Suk (School of Medicine, Wonkwang University) Oh, Yeon-Kyun (School of Medicine, Wonkwang University) Oh, Kwang-Su (School of Medicine, Wonkwang University) Min, Bu-Kie (School of Medicine, Wonkwang University) Han, Du-Seok (School of Dentistry, Wonkwang University) Baek, Seung-Hwa (College of Natural Sciences, Wonkwang University) Chun, Seung-Ho (College of Life Science and Natural Resources, Wonkwang University) Lee, Gap-Sang (College of Life Science and Natural Resources, Wonkwang University) Lee, Seong-Keun (College of Oriental Medicine, Wonkwang University) Seong, Kang-Kyung (College of Oriental Medicine, Wonkwang University) Lee, Geon-Mok (College of Oriental Medicine, Wonkwang University) Jeon, Byung-Hoon (College of Oriental Medicine, Wonkwang University) Song, Ho-Jun (College of Oriental Medicine, Wonkwang University)
저널정보
경희한의학연구센터 International journal of oriental medicine : OM International journal of oriental medicine : OM 제1권 제2호
발행연도
2000.1
수록면
59 - 65 (7page)

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To clarify the toxic effect of oxidative stress, hydrogen peroxide $(H_{2}O_{2})-induced$ neurotoxicity was examined in cultured newborn mouse spinal motor neurons after spinal motor neurons were grown in the media containing various concentrations of glucose oxidase (GO). And also, the protective effect of Rhizoma gastrodiae extract against GO-induced neurotoxicity was evaluated. Cytotoxicity was expressed as a cell viability by 3-(4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide (MTT) assay. In this study, exposure of motor neurons to GO-induced cell death significantly, in a dose- and time-dependent manners in spinal motor neuron cultures. The decrease in cell viability of motor neurons damaged by GO was proventioned by Rhizoma gastrodiae extract. These results suggest that the neuroprotective effect of Rhizoma gastrodiae extract on GO-induced neurotoxicity may result from a attenuation of $H_{2}O_{2}-induced$ oxidative stress.

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