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논문 기본 정보

자료유형
학술저널
저자정보
Kang Jee Hyun (Department of Family Medicine, College of Medicine, Konyang University) Lee Yoon Young (Department of Family Medicine, College of Medicine, Korea University) Yu Byung Yeon (Department of Family Medicine, College of Medicine, Konyang University) Yang Beom-Seok (Biomedical Center, KIST) Cho Kyung-Hwan (Department of Family Medicine, College of Medicine, Korea University) Yoon Do Kyoung (Department of Family Medicine, College of Medicine, Korea University) Roh Yong Kyun (Department of Family Medicine, College of Medicine, Hallym University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제28권 제11호
발행연도
2005.1
수록면
1,263 - 1,269 (7page)

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Recently, it was reported that reduction in serum adiponectin levels is correlated with the incidence of breast cancer. As an effort to explain this, we screened various human breast cancer cell lines to identify those in which proliferation is directly controlled by adiponectin. Among the five tested cell lines, proliferation of MDA-MB-231 cancer cell was significantly suppressed by adiponectin within the range of physiological concentration. Furthermore, prolonged adiponectin treatment caused cell growth arrest and even apoptosis of MDA-MB-231. This result is the first to show that adiponectin can directly control cancer cell growth and provides a rationale for the theory that reduction in plasma adiponectin levels could be a risk factor for breast cancer.

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