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논문 기본 정보

자료유형
학술저널
저자정보
Kim, Sung-Tae (Department of Anatomy-Pointology, College of Oriental Medicine, Kyungwon University) Sung, Yun-Hee (Department to Physiology, College of Medicine, Kyung Hee University) Kim, Chang-Ju (Department to Physiology, College of Medicine, Kyung Hee University) Joo, Kwan-Joong (Department of Urology, College of Medicine, Sungkyunkwan Univeristy) Han, Seung-Ho (Department of Physiology, College of Medicine, Eulji University) Lee, Choong-Yeol (Department of Physiology, College of Oriental Medicine, Kyungwon University) Kim, Youn-Sub (Department of Anatomy-Pointology, College of Oriental Medicine, Kyungwon University)
저널정보
대한동의생리학회 동의생리병리학회지 동의생리병리학회지 제20권 제6호
발행연도
2006.1
수록면
1,672 - 1,677 (6page)

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Sarcodon aspratus is the mushroom of Telephoracea which was been classified into Alphllophorales. The aqueous extract of Sarcodon aspratus in known to have anti-tumor activity, immune modulatory effect, and anti-oxidative action. The descending pain control system consists of three major components: the periaqueductal gray (PAG) of the midbrain, the rostroventral medulla including the nucleus raphe magnus, and the spinal dorsal horn. Glutamate is the primary excitatory neurotransmitter in the brain. Glutamate ionotropic receptors are classified as N-methyl-D-aspartate (NMDA) receptor, ${\alpha}$-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor, and kainate receptor. In the present study, the modulation of Sarcodon aspratus on the ion currents activated by glutamate, NMDA, AMPA, and kainate in the acutely dissociated PAG neurons was investigated by nystatin-perforated patch-clamp technique under boltage-clamp condition. Sarcodon aspratus increased glutamate- and NMDA-induced ion currents were not increased by Sarcodon aspratus. The present results show that Sarcodon aspratus may activate the descending pain control system in rat PAG neurons through NMDA receptor.

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