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자료유형
학술저널
저자정보
Lee, Young-Jin (Department of Biochmistry, College of Pharmacy, Sungkyunkwan University) Nam, Suk-Woo (Department of Biochmistry, College of Pharmacy, Sungkyunkwan University) Seo, Dong-Wan (Department of Biochmistry, College of Pharmacy, Sungkyunkwan University) Ahn, Seong-Hoon (Department of Biochmistry, College of Pharmacy, Sungkyunkwan University) Ko, Young-Kwon (Department of Biochmistry, College of Pharmacy, Sungkyunkwan University) Sung, Dae-Suk (Department of Biochmistry, College of Pharmacy, Sungkyunkwan University) Han, Jeung-Whan (Department of Biochmistry, College of Pharmacy, Sungkyunkwan University) Hong, Sung-Youl (Department of Genetic Engineering, College of Life Science and Natural Resources, Sungkyunkwan University) Lee, Hyang-Woo (Department of Biochmistry, College of Pharmacy, Sungkyunkwan University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제20권 제3호
발행연도
1997.1
수록면
239 - 246 (8page)

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In the present study, liver regeneration rate (%) was increased up to 70% 3 days after partial hepatectomy (PH). Nitric oxide synthase (NOS) activity in liver tissue as well as serum nitrite/ nitrate content had no timed response, revealing no significant difference between shamoperated and partially hepatectomized rat liver. Contents of free methylarginines in liver tissue were increased biphasically in a time-dependent manner after PH. However, those in serum did not exhibit the same patterns as in liver. Taken together, the results suggest that $N^{G}$-monomethyl-L-arginine (MMA) and $ N^{G}, N^{G}$-dimethylarginine (DMA) play a role in inhibiting nitric oxide (NO) synthesis in regenerating rat liver because the increase of their contents was synchronized with NOS expression.

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