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자료유형
학술저널
저자정보
Chung, Kyeong-Soo (Department of Microbial Chemistry, College of Pharmacy, Seoul National University) Choi, Eung-Chil (Department of Microbial Chemistry, College of Pharmacy, Seoul National University) Kim, Byong-Kak (Department of Microbial Chemistry, College of Pharmacy, Seoul National University) Kim, Yang-Sup (Institute of Agricultural Science, Office of Rural Development) Park, Yong-Hwan (Institute of Agricultural Science, Office of Rural Development)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제5권 제1호
발행연도
1982.1
수록면
17 - 19 (3page)

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To develop potent anitumor polysac-charides from higher hungi of Korea the alcohol precipitated polysaccharides, which were obtained from hot water extracts of shake-cultured mycelia of eight species of basidiomycetes, were subjected to antitumor screening tests, using sarcoma 180 as a tumor cell. When administered i. p, at the dose level of 20mg/kg/day for ten days into the mice which were implanted with $1{times}10^{8}$ cells of sarcoma 180 twenty-four hour before the start of polysaccharide injection, the polysaccharides of Plutcus cervinus ISA-Pc-1004, Pleurotus pulmonarius, Hydnum repandum ISA-Hr-1006, and Laccaria laccata ISA-LI-1008 respectively showed inhibition ratios of 62.0%, 51.7%, 64.8%, and 57.8%. They were selected for further study, while those of Pancillus serotina ISA-Ps-1012, Laccaria amethystina ISA-La 1001, Pholiota adiposa ISA-Pa-1010, and Lepista spISA-Ls-1007 respectively showed inhibition ratios of -9.3%, 25.3%, 27.3% and 33.0%.

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