소아환자의 Vancomycin에 대한 약물사용 평가 (II) -제한항균제로 사용규제 강화 후의 효과

이정민; 이순실; 김영주; 신완균; 이병구; 이환종

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자료유형: 학술저널

저자정보: 이정민 (서울대학교병원 약제부) 이순실 (서울대학교병원 약제부) 김영주 (서울대학교병원 약제부) 신완균 (서울대학교병원 약제부) 이병구 (서울대학교병원 약제부) 이환종 (서울대학교병원 소아과)

저널정보: 한국의료질향상학회 한국의료질향상학회지 한국의료질향상학회지 제1권 제1호

발행연도: 1994.1

수록면: 32 - 43 (12page)

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The 'Pharmacy and Therapeutic Committee' decided to restrict the use of vancomycin which was categorized into restricted antimicrobials, among general, reserved and restricted antimicrobials. The committee also established prescribing guidelines of vancomycin in Seoul National University Hospital, May, 1991. Especially, the restricted antimicrobials should be used after approval by infectious disease specialist physician. A retrospective drug use evaluation (DUE) on vancomycin has been conducted to compare with the previous vancomycin DUE study in 1990. 'Criteria for DUE on vancomycin' was modified from Am J Hosp Pharm. Total 65 charts of patients were retrospectively reviewed from July 1991 to June 1992 in Seoul National University Children's Hospital. The justification of use was improved from 56% to 75% comparing with the previous study. In analyzing process indicators, several criteria including body temperature monitoring, WBC monitoring and use of concomitant antibiotics were well documented, but serum creatinine monitoring, culture and sensitivity test and level monitoring were infrequently performed, while the accepted level has been improved. Accepted level for appropriate initial dosage and duration of therapy were decreased. In outcome analysis, blood culture after discontinuing the drug was relatively well documented compared with the previous study. As the results, the approval vancomycin use was shown to be effective and rational in antibiotic therapy. And it is suggested that the above findings should be communicated to the medical staff, and a active intervention, such as feedback control, also be necessary for rational drug use.

#Drug use evaluation #Vancomycin #Pediatrics #Restricted antimicrobials #Approval

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