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논문 기본 정보

자료유형
학술저널
저자정보
고창순 (서울대학교 의과대학 내과학교실)
저널정보
대한핵의학회 대한핵의학회지 대한핵의학회지 제20권 제2호
발행연도
1986.1
수록면
85 - 100 (16page)

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이 논문의 연구 히스토리 (5)

1986

자가면역성 갑상선질환에서 TSH 수용체 항체의 역활에 관한 연구
고창순 대한핵의학회지 1986.01 학술저널

1975

갑상선질환(甲狀腺疾患)에서의 혈장(血漿) 갑상선자극(甲狀腺刺戟)홀몬(T.S.H)치(値)에 관(關)한 연구(硏究)
고창순 ,  최강원 ,  강신일 외 2명 대한핵의학회 학술대회 1975.01 학술대회자료
갑상선질환(甲狀腺疾患)의 진단에 있어서의 문제점
고창순 대한핵의학회지 1975.01 학술저널

1972

갑상선자극(甲狀腺刺戟)홀몬의 방사면역측정(放射免疫測定) - 제1편(第1編) 각종(各種) 갑상선질환(甲狀腺疾患)에 있어서 혈중(血中) TSH의 변동(變動)
고창순 ,  이홍규 ,  노흥규 외 1명 대한핵의학회지 1972.01 학술저널

1969

방사선의학연구소(放射線醫學硏究所)에서 실시(實施)한 갑상선질환(甲狀腺疾患) 1,000 례(例)에 대(對)한 RI 기능검사(機能檢査)에 관(關)한 통계학적(統計學的) 관찰(觀察)
고창순 ,  이종헌 ,  홍창기 외 2명 대한핵의학회 학술대회 1969.01 학술대회자료

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To evaluate the clinical and pathogenetic roles of TSH receptor antibodies in autoimmune thyroid diseases, TBII were measured by TSH-radioreceptor assay methods in 352 patients with Graves' disease, 108 patients with other thyroid diseases and 69 normal persons. The normal range of TBII activity was less than 15%. The frequencies of detectable TBII in 169 patients with untreated Graves' disease, 31 patients with hyperthyroidism under treatment and 70 patients with euthyrodism under treatment were 92.4%, 87.1% and 54.3% respectively. However 12 (21.8%) out of 55 patients who have been in remission more than one year after discontinuation of antithyroid drugs treatment had detectable TBII activities in their sera. In 196 patients with untreated Graves' disease, the frequency of TBII increased by increasing size of goiter and the frequency of proptosis was significantly high in patients whose TBII activities were more than 60%. TBII activities were roughly correlated with total $T_3,\;T_4$ and free $T_4$ index but low $\gamma^2$ value(less than 0.1). In 67 patients with Graves' disease who were positive TBII before antithyroid drugs treatment, TBII activities began to decrease from the third months and it was converted to negative in 35.8% of patients at 12 months after treatment. There were no significant differences of the declining and disappearing rates of TBII activities between high dose and conventional dose groups. TBII activities were significantly increased initially (2-4 months) and then began to decrease from 5-9 months after $^{131}I$ treatment. There were two groups, one whose TBII activities decreased gradually and the other did not change untill 12 months after subtotal thyroidectomy. Although preoperative clinical and laboratory findings of both groups were not different, TBII activities of non-decreasing group were significantly higher than those of decreasing group$(74.6{\pm}18.6%\;vs\;39.2{\pm}15.2%;\;P<0.01)$. Thirty three(55.9%) out of 59 patients with Graves' disease relapsed within 1 year after discontinuation of antithyroid drugs. The positive rate of TBII at the end of antithyroid drug treatment in relapse group(n=33) was significantly higher than those in remission group (n=26) (63.6% vs 23.1%; P &lt; 0.05). The mean value of TBII activities at the end of antithyroid drug treatment in relapse group was significantly elevated $(29.7{\pm}21.4%\;vs\;14.7{\pm}11.1%,\;P<0.05)$. Positive predictive value of TBII for relapse was 77.8%, which was not different from those of TRH nonresponsiveness(78.6%). The frequencies of detectable TBII in 68 patients with Hashimoto's thyroiditis, 10 patients with painless thyroiditis and 5 patients subacute thyroiditis were 14.7%, 20% and 0%, respectively. However in 25 patients with primary nongoitrous myxedema, 11 patients(44%) showed TBII activities in their sera. 9 out of 11 patients who had TBII activities in their sera showed high TBII activities(more than 70% binding inhibition) and their IgG concentrations showing 50% binding inhibition of $^{125}I-bTSH$ to the TSH receptor were ranges of 0.1-2.6 mg/dl. One patient who had high titer of TBII in her serum delivered a hypothyroid baby due to transplacental transfer of maternal TBII. These findings suggested that 1) TSH receptor antibodies are closely related to a pathogenetic factor of Graves' hyperthyroidism and of some patients with primary non-goitrous myxedema, 2) measurement of TSH receptor antibodies is helpful in evaluating the clinical outcome of patients with Graves' disease during antithyroid drug treatment and in predicting the neonatal transient hypothyroidism of baby delivered from primary myxedema patients. 3) there are 2 or more different types of TSH receptor antibodies in autoimmune thyroid diseases including one which stimulates thyroid by binding to the TSH receptor and another which blocks adenylate cyclase stimulation by..

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