자외선 차단제의 SPF 지수와 피부자극지수와의 상관성 연구

김종원; 서수경; 최주영; 박창원; 서경원; 김규봉; 김광진; 김재희; 이선희

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자료유형: 학술저널

저자정보: 김종원 (식품의약품안전청 국립독성연구원 안전성평가과) 서수경 (식품의약품안전청 국립독성연구원 안전성평가과) 최주영 (식품의약품안전청 국립독성연구원 안전성평가과) 박창원 (식품의약품안전청 국립독성연구원 안전성평가과) 서경원 (식품의약품안전청 국립독성연구원 안전성평가과) 김규봉 (식품의약품안전청 국립독성연구원 안전성평가과) 김광진 (식품의약품안전청 국립독성연구원 안전성평가과) 김재희 (식품의약품안전청 국립독성연구원 안전성평가과) 이선희 (식품의약품안전청 국립독성연구원 안전성평가과)

저널정보: 한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology 제10권 제4호

발행연도: 2002.1

수록면: 246 - 252 (7page)

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In recent years, the safety of sunscreens has been challenged based on the reports of their adverse effect on users; dermatitis, allergic contact dermatitis and photo allergic contact dermatitis. The unscientific idea that higher SPF sunsreen is good for health mealeads many users to tend to prefer higher SPF sunscreen. In the toxicological aspect, the need to investigate the safety of sunscreens is steadily increasing. However, there were few studies on the correlation between sun protection factor (SPF) and the safety of sunscreens. The objective of this study was to assess whether there was a correlation between SPF and the safety of sunscreens. We measured in vitro SPF index using homosalate as a standard and examined the toxicity tests such as primary skin irritation tests, ocular irritation test and skin sensitization test. Homosalate (HS), octyl methoxycinnamate (OMC), octyl salicylate (OS), octocrylene (OC) as UVB organic filter and benzophenone-3 (BP3), butyl methoxy dibenzoil methane (BMDM) as UVA organic filter, and titanium dioxide (TD), zinc oxide (ZO) as inorganic filters were used. The skin irritation indexes in rabbits treated with HS, OMC, OS, BP3, and BMDM were significantly increased as SPF indices were increased. Neither ocular irritation in rabbits nor skin sensitization in guinea pigs were increased. It suggests that there might be a good correlation between SPF and the skin irritation indices of organic UV filters and skin irritation might be one of most sensitive index to assess the safety of sunscreens.

#sunscreens #SPF index #cosmetic safety #organic filters #skin irritation

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