지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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The purpose of this study was to determine the influence of assay error for improved pharmacokinetic modeling and simulation of vancomycin on the Bayesian and nonlinear least squares regression analysis in 24 Korean gastric cancer patients. Vancomycin 1.0 g was administered intravenously over 1 hr every 12 hr. Three specimens were collected at 72 hr after the first dose from all patients at the following times, at 0.5 hr before regularly scheduled infusion, at 0.5 hr and 2 hr after the end of 1 hr infusion. Serum vancomycin levels were analyzed by fluorescence polarization immunoassay technique with TDX-FLX. The standard deviation (SD) of the assay over its working range had been determined at the serum vancomycin concentrations of 0, 20, 40, 60, 80 and $120{\mu}g/ml$ in quadruplicate. The polynomial equation of vancomycin assay error was found to be SD $({\mu}g/ml)=0.0224+0.0540C+0.00173C^2$ ($R^2=0.935$). There were differences in the influence of weight with vancomycin assay error on pharmacokinetic parameters of vancomycin using the nonlinear least squares regression analysis but there were no differences on the Bayesian analysis. This polynomial equation can be used to improve the precision of fitting of pharmacokinetic models to optimize the process of model simulation both for population and for individualized pharmacokinetic models. The result suggests the improvement of dosage regimens for the better and safer care of patients receiving vancomycin.
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참고문헌 (31)
참고문헌 신청
Kirby, W. M / 1984 / Vancomycin therapy of severe staphylococcal infections / J. Antimacrob. Chemother 14:73
Watanakunakorn, C / 1982 / Treatment of infections due to methicillin-resistant staphylococcus aureus / Ann. Intern. Med 97:376
Sorrell, T. C / 1982 / Vancomycin therapy for methcillin-resistant staphylococcus aureus / Ann. Intern. Med 97:344
Harris, C. M / 1983 / Vancomycin structure and trasformation / J. Am. Chem. Soc 105:6915
Watanakunakorn, C / 1981 / The antibacterial action of vancomycin / Rev. Infect. Dis 3:210
Watanakunakorn, C / 1982 / Treatment of infections due to methicillin-resistant staphylococcus aureus / Ann. Intern. Med 97:376
Sorrell, T. C / 1982 / Vancomycin therapy for methcillin-resistant staphylococcus aureus / Ann. Intern. Med 97:344
Harris, C. M / 1983 / Vancomycin structure and trasformation / J. Am. Chem. Soc 105:6915
Watanakunakorn, C / 1981 / The antibacterial action of vancomycin / Rev. Infect. Dis 3:210
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